Factor VIII Antigen in Factor VIII Inactivated Plasma

At the July 17–21, 2021 meeting of the International Society on Thrombosis and Haemostasis, the Precision BioLogic Inc. and the Affinity Biologicals, Inc. research team presented a poster that demonstrates how inactivated factor VIII reagent preparations that are employed for factor VIII activity assays and inhibitor assays may contain factor VIII that is detectable by […]

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Bleeding Disorders

Aug 19 2021

george

Factor VIII Antigen Enzyme Immunoassay

The Precision BioLogic Inc. and the Affinity Biologicals, Inc. research team presented a poster describing their factor VIII antigen immunoassay recovery of various therapeutic concentrates at the July 17–21, 2021 meeting of the International Society on Thrombosis and Haemostasis. The poster is now available for your download: Ni R, Erb P, DellaMaestra, J, Atkinson H,Foulon […]

Bleeding Disorders

Thrombosis in VWF and Hemophilia

From Crystal Wilson: Hello George, I am writing to ask if you could help me to understand how, on rare occasions, patients suffering from bleeding disorders such as von Willebrand disease or hemophilia have suffered from hypercoagulable episodes such as pulmonary emboli or deep vein thrombosis. Thanks. Hello, Crystal, I sent your question to several […]

Bleeding Disorders

Chromogenic Factor IX Assay

The Precision BioLogic Inc. and the Affinity Biologicals, Inc. research team presented a poster describing the recovery characteristics of a new chromogenic factor IX assay at the July 17–21, 2021 meeting of the International Society on Thrombosis and Haemostasis. The poster is now available for your download: Tara Quinton, Rachel Clarke, John Fraser, Karen M. […]

Bleeding Disorders

August, 2021 Quick Question

Our August, 2021 Quick Question is “Which factor deficiency causes the smallest risk of bleeding?” Please answer at your convenience. This question may lead us to a discussion of the current research developments for safer anticoagulant preparations.

Bleeding Disorders

July, 2021 Quick Question: Covid Inflammatory Cell Results

Our July, 2021 Quick Question was, “Which cell is the main cause of thrombo-inflammation in a COVID-19 infection?” We had 43 respondents to our selections: Endothelial cell: 35% [15] Platelet: 44% [19] Monocyte-macrophage: 12% [5] polymorphonuclear neutrophil: 9% [4] There’s no right answer, as all of these cells are involved in inflammation, however, many who […]

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Quick Question Archive

Jul 28 2021

george

Chromogenic Factor IX Assay

Click here to see the Precision BioLogic research team’s latest poster, Quinton T, Clarke R, Fraser J, Black KM, Sadeghi-Khomami A. Validation of a New Kit for the Quantitative Determination of Chromogenic Factor IX Activity. This poster was presented at the July 17–21 ISTH meeting.

Bleeding Disorders

Additional Source for Blue-closure Tubes

Here is a July 22, 2021 FDA announcement indicating an emergency use authorization for BD Vacutainer blue-closure tubes sourced from the UK. Thanks to Elaine Benoit, Precision BioLogic Inc., for drawing our attention to the announcement. The FDA is attempting to address the blue-closure tube shortage we discussed in prior posts.

Specimen Management

VITT Mechanism Nature Preview

Here is a research article that was rushed to print in the July 7, 2021 Nature that describes the precise pathophysiology of vaccine-induced immune thrombotic thrombocytopenia [VITT]. VITT is the critical 1/60,000 incidence adverse event associated with the adenoviral vector employed in the Astra-Zeneca and Johnson and Johnson vaccines, among others. VITT resembles heparin-induced thrombocytopenia […]

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Platelet Function Testing

Jul 11 2021

george

More on Platelet Function Testing

From Dave McGlasson: George, Aquino in a recent article in CAP Today titled, “Puzzling out platelet function disorders,” posted July 6 on Fritsma Factor, extolled the virtues of light transmittance aggregometry [LTA] on platelet rich plasma [PRP] as the reference [“gold standard”] method to assess platelet aggregation disorders. This may have been true years ago […]

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Platelet Function Testing

All Posts

Factor VIII Antigen in Factor VIII Inactivated Plasma

Factor VIII Antigen Enzyme Immunoassay

Thrombosis in VWF and Hemophilia

Chromogenic Factor IX Assay

August, 2021 Quick Question

July, 2021 Quick Question: Covid Inflammatory Cell Results

Chromogenic Factor IX Assay

Additional Source for Blue-closure Tubes

VITT Mechanism Nature Preview

More on Platelet Function Testing

George Fritsma MS MLS

Cheat Sheets from George

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