Mar 1 2022

george

March 2022 Cheat Sheet

Our March 2022 Cheat Sheet is linked. If you’d like to receive the Cheat Sheet in your mailbox, please send your email address to [email protected] and we will add you to our distribution list.

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Cheat Sheets

Mar 1 2022

george

March 2022 Quick Question: Measuring Anti-Xa DOACs

Please review and answer our March 2022 Quick Question, submitted by colleague and coagulation expert Dave McGlasson. Although the US FDA has never approved the chromogenic anti-Xa assay for the direct oral anticoagulants rivaroxaban and apixaban, calibrators and controls are available from several distributors. Many facilities are called upon to assay for plasma concentration in […]

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Anticoagulant Therapy

Mar 1 2022

george

February, 2022 QQ Response: Platelet Aggs

Thanks to our 57 FF participants for your responses to our February 2022 Quick Question. The question stem was: “What single agonist is your first choice to measure platelet response to aspirin?” ADP: 14% [8] TRAP: 2% [1] Collagen: 2% [1] Epinephrine: 28% [16] Arachidonic acid: 54% [31] Although this question is a poll, my […]

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Arterial Thrombosis

Feb 27 2022

george

CAP Today: Specimen Collection

Here are two CAP Today front-page articles featuring Dorothy Adcock, MD and Richard Marlar, PhD regarding coagulation specimen collection: September 2021: In Coag Collections, Every Detail Counts February 2022: Steps to Preventing Coag Test Processing Error These are richly referenced articles that draw attention to International Council for Standardization in Haematology guidelines.

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Specimen Management

Feb 18 2022

george

Measuring DOACs

Here is a helpful article from the January 17, 2022 issue of CAP Today: “Measuring Direct Oral Anticoagulants—When, How.”

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Anticoagulant Therapy

Feb 18 2022

george

PIVKA

George is updating a book chapter and asks if there is a reason to continue using the phrase “proteins induced by vitamin K absence/antagonists” [PIVKA], now termed des-gamma-carboxy- II, VII, IX, or X. Does any laboratory continue to offer a PIVKA assay?

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Anticoagulant Therapy

Feb 18 2022

george

FDP and D-dimer

A question for discussion. Is there any clinical reason to test for both fibrin degradation products [FDPs] and D-dimer?

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Fibrinolysis

Feb 10 2022

george

COVID-19: VWF/ADAMTS13 Balance

Thanks to Brandon Michael Henry MD, Cincinnati Children’s Hospital Medical Center for drawing attention to his award-winning review, co-authored with Drs. Emmanuel Favaloro and Giuseppe Lippi, which details the relationship between von Willebrand factor and ADAMTS13 and applies the VWF/ADAMTS13 activity ratio to the thrombotic progression of the SARS-CoV2 infection. The authors review 67 primary […]

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Arterial Thrombosis

Jan 30 2022

george

February 2022 Cheat Sheet

Our February 2022 Cheat Sheet is attached. Please contact George at [email protected] if you’d like a push copy to arrive in your mailbox.  

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Cheat Sheets

Jan 30 2022

george

February, 2022 Quick Question: Platelet Aggs

Our February 2022 Quick Question asks, What single agonist is your first choice to measure platelet response to aspirin? The typical aggregation profile includes several agonists, however it may be that one is more sensitive to aspirin’s antiplatelet effect than the others. As always, please add your comments below.

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Antiplatelet Therapy