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ISTH Covid Antithrombotics Guidelines

On Wednesday, 8-3-22, the ISTH published comprehensive guidelines recommending for or against antithrombotic agents for Covid at defined levels of severity. Below are the task force guidelines and an editorial describing the research considerations behind guideline development. Schulman S, Sholzberg M, Spyropoulos AC, et al. ISTH guidelines for antithrombotic treatment in COVID-19. JTH 2022, DOI: […]

Anticoagulant Therapy

August 2022 Cheat Sheet

Here’s a link to our August 2022 Cheat Sheet, which will also appear in your inbox this week. It may contain a hint to this month’s Quick Question.

August 2022 Quick Question: LAC Testing

Our August 2022 Quick Question addresses lupus anticoagulant testing, a member of the standard thrombophilia screening profile. “You test for lupus anticoagulant [LAC] using a low-PL PTT reagent and a hex-phase high-PL mix. The mix results are 10 seconds shorter than the first test. What do you conclude?” The question illustrates the PTT-based LAC test […]

Lupus Anticoagulant

July 2022 QQ: Reduced concentration RIPA test.responses

Our July 2022 Quick Question asked, “What VWD subtype is identified using the reduced concentration RIPA test?” We received 30 votes. Here are our answers: VWD Type 1: 10% [3] VWD Type 1C: 0 VWD Subtype 2A: 3% VWD Subtype 2B: 87% VWD Subtype 2M: 0 VWD Subtype 2N: 0 VWD Type 3: 0 Few […]

Bleeding Disorders

Viscoelastometry for Thrombophilia

Please comment here if you are using viscoelastometry–Sonoclot, TEG 5000, TEG 6S, ROTEM, or Quantra–to detect a prothrombotic state, and please provide the parameters you employ. For detailed information, click Reda S, Morimont L, Douxfils J, Rühl H. Can we measure the individual prothrombotic or prohemorrhagic tendency by global coagulation tests? Hämostaseologie 2020;40:364–78.

ISTH Poster: FVIII Deficient Plasma with VWF

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Kesavan N, Rahman M, Sadeghi-Khomami A, Black KM, Wood A. Performance of FVIII deficient plasma with VWF in the activity measurement of FVIII replacement products in plasma samples using […]

Bleeding Disorders

ISTH Poster: Chromogenic FIX Activity Assay

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Quinton T, Fraser J, Black KM, Sadeghi-Khomami A. Performance of a chromogenic factor IX activity assay in the recovery of factor IX replacement therapies, Abstract PB1183. Their data illustrate […]

Bleeding Disorders

Low Titer Group O Whole Blood

Here is a thought-provoking article by Charna Albert from the June 2022 issue of CAP Today entitled, “Lining up for low titer O whole blood in trauma care.” Please comment about your use of whole blood or refrigerated platelet concentrate to manage trauma-induced coagulopathy.

Bleeding Disorders

July 2022 Cheat Sheet

Here is our July 2022 Cheat Sheet, which will also appear in your mailbox.

July 2022 QQ: Reduced concentration RIPA test.

Our July 2022 Quick Question asks, “What von Willebrand disease [VWD] subtype is identified using the reduced concentration ristocetin-induced platelet aggregometry [RIPA] test?” Many of the VWD types and subtypes are currently identified using molecular diagnosis, however, the “legacy” phenotypic tests often provide a speedy and inexpensive shortcut. This may be one such case. Please […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question