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July 2022 QQ: Reduced concentration RIPA test.responses

Our July 2022 Quick Question asked, “What VWD subtype is identified using the reduced concentration RIPA test?” We received 30 votes. Here are our answers: VWD Type 1: 10% [3] VWD Type 1C: 0 VWD Subtype 2A: 3% VWD Subtype 2B: 87% VWD Subtype 2M: 0 VWD Subtype 2N: 0 VWD Type 3: 0 Few […]

Bleeding Disorders

Viscoelastometry for Thrombophilia

Please comment here if you are using viscoelastometry–Sonoclot, TEG 5000, TEG 6S, ROTEM, or Quantra–to detect a prothrombotic state, and please provide the parameters you employ. For detailed information, click Reda S, Morimont L, Douxfils J, Rühl H. Can we measure the individual prothrombotic or prohemorrhagic tendency by global coagulation tests? Hämostaseologie 2020;40:364–78.

ISTH Poster: FVIII Deficient Plasma with VWF

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Kesavan N, Rahman M, Sadeghi-Khomami A, Black KM, Wood A. Performance of FVIII deficient plasma with VWF in the activity measurement of FVIII replacement products in plasma samples using […]

Bleeding Disorders

ISTH Poster: Chromogenic FIX Activity Assay

Yesterday, July 12, 2022, at the ISTH annual meeting in London, England, the research staff of Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada presented the poster: Quinton T, Fraser J, Black KM, Sadeghi-Khomami A. Performance of a chromogenic factor IX activity assay in the recovery of factor IX replacement therapies, Abstract PB1183. Their data illustrate […]

Bleeding Disorders

Low Titer Group O Whole Blood

Here is a thought-provoking article by Charna Albert from the June 2022 issue of CAP Today entitled, “Lining up for low titer O whole blood in trauma care.” Please comment about your use of whole blood or refrigerated platelet concentrate to manage trauma-induced coagulopathy.

Bleeding Disorders

July 2022 Cheat Sheet

Here is our July 2022 Cheat Sheet, which will also appear in your mailbox.

July 2022 QQ: Reduced concentration RIPA test.

Our July 2022 Quick Question asks, “What von Willebrand disease [VWD] subtype is identified using the reduced concentration ristocetin-induced platelet aggregometry [RIPA] test?” Many of the VWD types and subtypes are currently identified using molecular diagnosis, however, the “legacy” phenotypic tests often provide a speedy and inexpensive shortcut. This may be one such case. Please […]

Bleeding Disorders

June, 2022 Quick Question Summary: VET Instruments

Our June 2022 Quick Question asked, “What viscoelastometry [VET] equipment is employed in your ER or OR?” Out total response was 22 participants. Answers: Thromboelastograph 5000 [TEG]: 18% [4] Thromboelastograph 6S [TEG]: 18% [4] Thromboelastometry [ROTEM]: 23% [5] Quantra Qplus: 0 Sienco Sonoclot: 0 Our lab doesn’t manage VET testing: 41% [9] At the June […]

Global Hemostasis Assays

Heparin Curve to Measure DOACs?

Does your facility measure rivaroxaban or apixaban using a chromogenic substrate anti-Xa assay based on unfractionated heparin [UFH] calibrators or UFH-low molecular weight heparin [UFH-LWMH] ‘hybrid” calibrators, or do you require rivaroxaban and apixaban calibrators? I [Geo] received a 6-22-22 response from international hemostasis expert Robert Gosselin, who cited several references. Many of us use […]

Anticoagulant Therapy

OR Hemostasis Presentation

I [Geo] will present “Hemostasis in the Operating Room” at the American Society for Clinical Laboratory Sciences Joint Annual Meeting in Grand Rapids, Michigan, Wednesday, tomorrow, June 29, 1:45–2:45 EDT. The “JAM” will be a hybrid meeting, so presentations will be available on-site or online. My talk covers anticoagulation and coagulopathy management and features the […]

Global Hemostasis Assays

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question