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Poster: Effect of High-Dose DOACs and DOAC-Remove on LA Detection

Click here to see our ISTH poster, Rahman M, Sadeghi-Khomami A, Black KM. Effect of high-dose direct anticoagulant drugs and DOAC-Remove™ on lupus anticoagulant detection by a hexagonal phase phospholipid assay, 2023. [ISTH Abstract PB1147].

Specimen Management

FDA Approves Hemophilia A Gene Transfer Rx

Today, July 3, 2023, the FDA approved the use of BioMarin’s Roctavian® [valoctocogene roxaparvovec] for treating adults with severe hemophilia A without inhibitors. The FDA also approved BioMarin’s companion diagnostic, AAV5 DetectCDx, which identifies the patients most likely to benefit from Roctavian. Click here for the LinkedIn announcement. Click here for a provocative FirstWord PHARMA […]

Bleeding Disorders

July 2023 Quick Question

Our July Quick Question asks, “How long may platelet-poor plasma be stored at –20 degrees C?” This reflects our recent series of posts regarding hemostasis specimen management, including our June 21 discussion on Specimen Transport. Many specimen management issues are up for review and will be reflected in a new edition of the CLSI Guideline […]

Quick Question Archive

July 2023 Cheat Sheet

Click here to see our July 2023 Cheat Sheet. If you’ve subscribed [signup is at the bottom of our “Posts” page, you will also receive your Cheat Sheet by email.

June, 2023 Quick Question Review

Our June 2023 Quick Question asked, “Name the bispecific antibody-based FVIII inhibitor bypass agent.” Our 68 respondents answered… Caplacizumab [Cablivi]: 3 [4%] Eculizumab [Soliris]: 8 [12%] Emicizumab [Hemlibra]: 53 [78%] Eloctate: 3 [4%] Jivi: 1 [2%] Genentech’s emicizumab is the bispecific antibody that bypassed FVIII in to join FIX to FX, activating FX. Emicizumab is […]

Quick Question Archive

Mother and Daughter With Hematomas

George, My daughter and I seem to have a tendency to bruise easily. She just got a big bruise the other day from a surfing accident and that episode started the conversation of why we bruise. I wonder if it could be a genetic possibility. We also are both blood type O and “23 and […]

Bleeding Disorders

Specimen Transport

In further followup to our June 15, 2023, Freezing Coagulation Specimens post, here is a June 2023 CAP Today article about specimen transport. In follow-up, I [Geo] contacted Dr. Joe Wiencek, who was referenced in the article. Here is my question and his answer: Dr. Wiencek, I’m writing in response to the CAP June 2023 […]

Specimen Management

More on Specimen Storage

Frequent contributor and coag expert Dave McGlasson sent this linked scanned copy of a 1985 article in his state newsletter, “The Texan.” The article documents factor VIII deterioration when stored at –20°C. This is a follow-up to our June 15, 2023 post, Freezing Coagulation Specimens.

Coagulation Factors

Coag Conversation Part 3: VWF and ADAMTS13: Cardiovascular Diseases

Introducing The Many Faces of von Willebrand Factor or, von Willebrand Factor, ADAMTS13, Malignancy and Beyond Part 3: von Willebrand Factor and ADAMTS13; Thrombotic Mechanisms and Cardiovascular Diseases. This 30″ talk features George A. Fritsma, MS, MLS, proprietor of The Fritsma Factor, Your Interactive Hemostasis Resource, and Emmanual Favaloro, PhD, Principal Hospital Scientist at the […]

Arterial Thrombosis

Freezing Coagulation Specimens

Yesterday, June 14, 2023, I [Geo] received two questions about coagulation plasma specimen management. Heather DeVries, Indiana University, asked if there were data supporting the CLSI two-week maximum for storing plasma frozen at –20°C, and Jessica Warner, Kettering Health, asked how soon after thawing you must run an assay. The CLSI guideline H21-A5, Clinical and […]

Specimen Management

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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