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Please Provide Comments: Prolonged PT and PTT, Retinal Bleed

I’m [Geo] seeking comments about this case of a 65-YOA female on no anticoagulant with retinal hemorrhage and no other bleeding symptoms: Coag 1/18/24 1/19/24 1/20/24 1/21/24 PT 16.9 15.6 PTT 53 44 TCT 17 FG 592 576 FII 83 FV 79 FVIII 167 FIX 71 FX 75 FXI 80 VWF:Ag 121 VWF:RCo 147 D-dimer […]

Bleeding Disorders

WFH Statement on Cryoprecipitate

The World Federation of Hemophilia [WFH] is deeply concerned by the inclusion of pathogen-reduced and non-pathogen-reduced cryoprecipitate in the World Health Organization’s 23rd Essential Medicines List [EML] and Essential Medicines List for Children [EMLC]. Click here for the 12-23-23 WFH statement.

Bleeding Disorders

January 2024 Cheat Sheet

Here’s to a successful 2024. Click here for your January 2024 Cheat Sheet. You will receive your copy via email within a few days.

January 2024 Quick Question: Platelet Function Tests

Our January 2024 question is a poll submitted by Dave McGlasson, asking, “What platelet function test do you use?” While light transmittance aggregometry [LTA] has been available since the mid-1960s and is regarded by many as the reference method for platelet function testing, many have switched to the simpler whole blood aggregometry [WBA]. Our answers […]

Bleeding Disorders

December 2023 Quick Question Summary: VWD Subtype 2B

Our December 2024 Quick Question, “How do you test for VWD subtype 2B?” attracted 31 responses as follows: RIPA: 15 [48%] VWFAg: 2 [7%] VWF:CB: 5 [16%] VWF:RCo: 6 [19%] Multimeric analysis: 3 [10%] Our question drew this comprehensive discussion from Dr. Emmanuel Favaloro on Tuesday, December 12, 2023: Hi George, I have been following […]

Bleeding Disorders

Coag Factor Nomenclature

In a follow-up to our September 8, 2023 Arabic Numerals discussion, refer to Dave McGlasson’s Clot Club entry “Do We Need to Standardize Coagulation Nomenclature?” Dave includes a comprehensive review of procoagulant functions, names, and properties.

Coagulation Factors

FVII Deficiency

I [Geo] received this post on Monday, December 18: Hi George, I have a few questions that I was hoping you could help me with. I’m a patient with factor 7 deficiency and have a background in nursing. I was diagnosed at 49% but have had issues with fluctuations in percentages between standalone labs and […]

Bleeding Disorders

VWF in Malignancy

In the Rutgers CLSC 5124 Advanced Hemostasis graduate course, a participant responded to the question, “What do both Dr. Favaloro and Dr. Henry indicate about the role of platelets in metastatic carcinoma?.” The question referred to our Coag Conversations with Dr. Emmanuel Favaloro, The Many Faces of VWF. and with Dr. Brandon Henry, What Have […]

Arterial Thrombosis

VWF in Cardiac Disorders

In the Rutgers CLSD 5124 Advanced Hemostasis graduate course, a participant responded to the question, “Show how VWF and platelets appear to be involved in cardiac insufficiency and atrial fibrillation.” The question referred to our Coag Conversation with Dr. Emmanuel Favaloro, The Many Faces of VWF. The response: VWF is a glycoprotein heavily engaged in […]

Arterial Thrombosis

Acquired Hemophilia, rpVIII, and Bethesda Titer

Here is a 12-2-23 email from Hrvoje Melinšćak MD, Consultant in Haematology, the Warren Alpert Medical School of Brown University, Rhode Island Hospital/The Miriam Hospital. I would enquire regarding rpFVIII’s impact on inhibitor titre assessment through the Bethesda assay in a case regarding acquired haemophilia A. Does significant background rpFVIII (Obizur) concentrate lend to significant […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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