Precision BioLogic Round Table Discussion

Precision BioLogic Inc., the folks who sponsor the Fritsma Factor, hosted a June 19-20 roundtable at their beautiful new facility in Dartmouth, Nova Scotia, across the harbor from Halifax. Participants were Dorothy (Dot) Adcock-Funk, MD, Medical and Laboratory Director of Esoterix Coagulation in Englewood, CO; Kandice Kottke-Marchant, MD, PhD, Chair of the Department of Pathology […]

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Jun 26 2008

george

New Chest Journal Antithrombotic Guidelines

Dr. Marisa B. Marques, director of the University of Alabama at Birmingham Hospital Special Coagulation Laboratory reports the American College of Chest Physicians Eighth ACCP Conference on Antithrombotic and Thrombolytic Therapy has released “Antithrombotic and Thrombolytic Therapy: 8th Edition Guidelines.” The guidelines are available free online to non-subscribers at Chest 2008:133 (6 suppl) . This […]

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Factor Levels in Hemophilia

Mary Paoli of Palmetto Health asks, “When hemophilia is classified as severe, moderate or mild, are factor VIII activity levels (FVIII:C), reported in percentage, or factor VIII antigen (FVII:Ag), reported in U/dL? Thank you for your question, Mary. When a newborn boy is at risk of hemophilia, his plasma is tested using the plasma-based factor […]

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Monitoring von Willebrand Disease Therapy

Eight participants answered our June 16-21 hemostasis question asking how we monitor von Willebrand disease therapy. Three employ the von Willebrand ristocetin cofactor assay (VWF:RCo, VWF activity). This is the method recommended by the Scientific Sub-Committee on von Willebrand Factor of the International Society of Thrombosis and Haemostasis (ISTH-SSC on VWF). However, four prefer the […]

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Von Willebrand Disease Therapy

On June 1 I provided two hemostasis lectures for Dr. Ingrid Oakley’s Nurse Anesthesia course at the University of Alabama at Birmingham. I particularly like doing these lectures because I admire and respect Dr. Oakley; UAB’s remote online real-time technology is cool, and the students are serious, bright, and engaging. These are experienced nurses working […]

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Does Hemolysis Affect the Anti-Xa?

Here is another question from my friend and colleague, Vicki Cardone, Hematology Supervisor at Children’s Hospital of Alabama, just across the street from my own University of Alabama Hospital: Would a hemolyzed sample cause the anti-Xa value to be falsely decreased as it would give a stronger color reaction, or am I just way off? […]

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Quick Question: Heparin Detection

Eleven of our over 300 subscribers participated in last week’s quick question, which was: “How does your laboratory detect unrecorded heparin in a plasma specimen?” Here are the answers: Eight (73%) use the thrombin clotting time, two just treat the specimen with hepzyme, and one uses the anti-Xa heparin assay. It looks like no one […]

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More on Cranberry Juice

From Cynthia McKenzie, RN: Many years ago I knew of a patient who was stable on Coumadin. A PT/INR was drawn on a Thursday and it was therapeutic. On Friday evening she complained of nausea and requested cranberry juice. A 1/2 to 1 gallon container was brought in by a family member. She refused food […]

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Von Willebrand Disease: Collagen Binding Assay

Here is a June 6, 2008 message from Kim Kinney at Clarian in Indianapolis: Hi George, We are going to evaluate a kit for collagen binding. I remember at the Midwest Symposium this year Dr. Adcock commented on the type of collagen used in the kit and that one was better than another. From what […]

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Nurse Anesthesia: VWF Dosage Calculation

Here is an example of how to calculate the dosage of von Willebrand factor (VWF) for a patient with severe von Willebrand disease (VWD). The preparation used most in the US for VWF replacement is Humate P, a fractionated human plasma product rich in VWF. The computation example may also be applied to replacement factor […]

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All Posts

Precision BioLogic Round Table Discussion

New Chest Journal Antithrombotic Guidelines

Factor Levels in Hemophilia

Monitoring von Willebrand Disease Therapy

Von Willebrand Disease Therapy

Does Hemolysis Affect the Anti-Xa?

Quick Question: Heparin Detection

More on Cranberry Juice

Von Willebrand Disease: Collagen Binding Assay

Nurse Anesthesia: VWF Dosage Calculation

George Fritsma MS MLS

Cheat Sheets from George

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