All Posts

Algorithm for DOAC Dipstick Application

Click here for the open-access article: Harenberg J, Gosselin RC, Cuker A, et al. Algorithm for rapid exclusion of clinically relevant plasma levels of direct oral anticoagulants in patients using the DOAC dipstick: an expert consensus paper. Thromb Haemost. 2024;124:770–7. doi: 10.1055/a-2261-1811. PMID: 38316416. Abstract Background With the widespread use of direct oral anticoagulants (DOACs), there […]

Anticoagulant Therapy

Activated Protein Complex Concentrate in Emicizumab Prophylaxis

Here is a current open-access review describing APCC usage in emicizumab therapy: Sidonio RF Jr, Young G, Escuriola Ettingshausen C, et al. Activated prothrombin complex concentrate in patients receiving emicizumab prophylaxis: from evidence to clinical practice. Res Pract Thromb Haemost. 2025;9:102926. doi: 10.1016/j.rpth.2025.102926. PMID: 40808796; PMCID: PMC12346059. Abstract Nonfactor therapies (NFTs) such as emicizumab are increasingly […]

Bleeding Disorders

University of Kansas Article About TTP

Here is an editorial review article about TTP that appears in the Spring-Summer edition of the University of Kansas “Kansas Medicine” magazine, entitled “In Their Blood.” The article features X. Long Zheng, MD, PhD, KU pathology head, who provided our January 6, 2021 webinar, “von Willebrand Factor, Friend or Foe?“

Bleeding Disorders

Underfilled Citrate Tubes

Hi George. My name is Reynaldo Caparros. I know that it has been taught and drilled in our knowledge on how we should properly fill up blue tops. This has also resulted in numerous delays in patient care. My question is, are there any studies that have been done to check the possibility that short […]

Specimen Management

World Thrombosis Day Today, 10-13-25

Click here for World Thrombosis Day information.

Anticoagulation Therapy Review

Dr. Emmanuel Favaloro’s 2018 open access review article “Anticoagulation therapy in Australia” has received 10,000+ views! The article is available for free download at: https://lnkd.in/gfcsyW5s. If you prefer the updated version published in JCM in 2025, during and post COVID-19, then head to https://lnkd.in/gAnPWn_E for a free download.

Anticoagulant Therapy

An Experimental Oral FVIII Mimetic

Click here in Hemostasis Today for a brief discussion of a developing phase 1 oral FVIII mimetic: Wolfgang Miesbach: Jan Astermark at the BIC 2025 presented Potentially the First Oral FVIII Mimetic Treatment for Hemophilia A.

Bleeding Disorders

October 2025 Cheat Sheet

Click here to read your October 2025 Fritsma Factor Cheat Sheet. Your personal copy will arrive soon in your inbox. If you aren’t receiving the “push” Cheat Sheet, please complete the form on the right. While you’re there, please give your answer to this month’s Quick Question. Both the Cheat Sheet and Fritsma Factor are […]

October 2025 QQ: Reporting Assay Uncertainty Data

Please refer to our August 29, 2025 discussion, “Hemostasis Assay Statistical Variation.” In this post, we linked the article, Mullier F, Gouin-Thibault I, Meijer P, et al. Time to integrate measurement uncertainty in method comparison and interpretation of hemostasis laboratory assays. Res Practice Thromb Hemost 2025: 9, https://doi.org/10.1016/j.rpth.2025.102993. The authors contend that we should report uncertainty […]

Quick Question Archive

September 2025 QQ: Viscoelastometry Discussion

Our September 2025 Quick Question asked, “What viscoelastometry device is employed at your facility?” A modest group of thirteen participants answered… TEG 6s: 4 (31%) TEG 5000: 2 (15%) ROTEM: 5 (39%) Sonoclot: 0 Hemosonics Quantra: 2 (15%) The TEG 5000 was developed in 1948, and the Sonoclot in 1975; both represent the pioneering phase […]

Quick Question Archive

Load more

George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question