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What is Monoclonal Gammopathy of Thrombotic Significance?

Just when we thought there was nothing new in hemostasis, the June 2025 CAP Today front-page article by Karen Titus, Spectrum of Anti-PF4 Disorders Widens, ties together HITT, VITT, and what we have known as commonplace MGUS, here renamed MGTS, all fit together in the category, anti-PF4 disorders. I (Geo) recommend this excellent article that […]

July 2025 Cheat Sheet

Click here for your July 2025 Cheat Sheet. Also, watch for your “push” version that will hit your mailbox in a few days. If you would like to receive your copy via email, provide your contact information in the right-hand column. Fritsma Factor participation is free, and your comments are welcome.

July 2025 Quick Question: Hemophilia Therapeutics

At the June 21–25 ISTH meeting in Washington, DC, we heard several quality presentations describing the new hemophilia treatment materials, including updated EHL concentrates plus the bypassing, rebalancing, and gene transfer therapies. In follow-up, our July 2025 Quick Question asks you to select the choice that represents the recently approved rebalancing therapies. Please make your […]

Bleeding Disorders

June 2025 Quick Question Summary: Fibrinolysis

Our June 2025 Quick Question was a quiz that asked, “Which fibrinolysis component directly digests fibrin?” Our 51 respondents answered… Plasminogen: 12 (23%) Antiplasmin: 0 D-dimer: 1 (2%) Plasmin: 37 (73%) TPA: 1 (2%) The correct answer is #4, plasmin. In brief, plasminogen is a zymogen. Plasmin, the activated form of plasminogen, binds and digests […]

Differential Discussion: Hemophilia Part 2

On June 6, 2025, Malissa Norfolk and Dave Cabral posted George’s audio PowerPoint, “Have We Cured Hemophilia, Part 1?.” On June 25, Malissa and Dave posted “Have We Cured Hemophilia, Part 2?” Each video is 30″ long. Please feel free to watch and comment below.

Bleeding Disorders

DIC Update

On Monday, June 23, Ecaterina (Katy) Scarlatescu, MD, PhD, Department of Anaesthesia and Intensive Care, Fundeni Clinical Institute, University of Medicine and Pharmacy, Bucharest, Romania, chaired a plenary session of panelists at the ISTH annual meeting in Washington, DC, USA. The panel discussed the 2025 ISTH DIC definition and diagnostic guidelines we reported on June […]

Invent-VTE

In the ISTH annual meeting (June 21–25, 2025) I (Geo) met a representative of Invent-VTE, a non-profit dedicated to fostering international VTE research collaboration. Navigate to Hemostasis Agencies to see Invent-VTE‘s website and our complete list of hemostasis-related agencies.

Lab Assessment of FVIII Inhibitors

Click here for an open-access article describing the need for factor inhibitor assessment: Favaloro EJ, Curnow J, Pasalic L. Laboratory assessment of factor VIII inhibitors: when is it required? A perspective informed by local practice. J Clin Med. 2024;14:13. doi: 10.3390/jcm14010013. PMID: 39797095; PMCID: PMC11720995. See also our factor inhibitor discussions under the Bleeding Disorders heading.

Bleeding Disorders

Neutrophil Extracellular Traps

Neutrophil extracellular trap (NET) research has gained prominence beginning in perhaps 2010. I’ve attached an open-access review that illustrates NETs‘ functions and shows how NETs connect neutrophils with hemostasis. The article also documents how NETs participate in the process of thrombosis. Click to download Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular […]

Mixing Studies

From time to time I (Geo) get questions about mixing studies. Click here to access a series of past entries that are compiled in our Mixing Study category. Additionally, click on “Coagulation Mixing Studies” for my 30-minute narrated PowerPoint presentation.

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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