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CAP Survey Questions

From Kim Kinney at Clarian in Indianapolis: Hi George, Just started looking over the CAP version 06.17.2010 questions and there are a few that puzzle me. Statement HEM.22912 regarding stability of coag samples no longer mentions PTT samples that include heparin. Questions HEM.25150 and 25175 are revised/new and talk about instruments with integral automatic pipettors, […]

Does Heparin Affect LA Testing?

A question from “Bmolpus:” Hello, I am an emergency physician who has started an urgent care practice and find myself reviewing more patient records and getting more exposure to laboratory tests which were out of the scope of my previous ER practice. I have been reviewing the site and am curious to see if you […]

Hemolysis Shortens PTTs When Heparin is Present

I received this cheerful note from Nichola Marcus, a graduate of our UAB Clinical Laboratory Science program, now on the laboratory staff of Huntsville Hospital, Huntsville, Alabama: Hey George! Check out the AACC abstract poster D-54 from your former UAB student–I never would have guessed that my first abstract would be coag related. I have a question for you: Do you […]

Quick Question Summary: Mixing Studies

Here are the results of our June QQ on Mixing Studies: When performing a partial thromboplastin time (PTT) mixing study using reagent pooled normal plasma (PNP), what do you use as your correction/non-correction limit? a. Mixture PTT is within 10% of the PNP PTT result: 9 (14%) b. Mixture PTT is within 5 seconds of […]

Functional Protein C

I have this message from Theresa Nwagha, University of Nigeria Nsukka: I am performing a functional assay of protein C in pregnancy will need help with SOP. Not a routinely performed assay in my center. Hello, Dr. Nwagha, and thank you for your message. May I recommend you purchase thePrecision BioLogic Cryocheck Clot C test kit. The […]

Developing a Reference Interval

From D. Kaguni: I would like to know where I would find information on validation of a rare factor activity assay in which the test kit is quite expensive and performing the recommended 120 normal plasmas to create a reference range would be very expensive. I have inquired with CLSI and they do not have […]

Heparinase

Margaret Peters, MD at MHS Health asks: What coagulation tests may be run on samples previously treated with heparinase? Is any correction factor required for a quantitative assay? Are there any published guidelines on this topic? Thank you! Hello, Dr. Peters. Heparinase is manufactured by Ibex and distributed by Siemens Laboratory Diagnostics, Inc. as Hepzyme. It specifically digests […]

PTT Mixing Studies With Saline

Joe Lamb asked, “George, I’m working on mixing study procedures for my lab. I’ve read about a saline mix and I’m looking for a reference for the technique. I’m interested in a procedure and how to interpret the results. can you recommend something for me?” Hi, Joe. I apologize for being a little slow on […]

Coagulation Testing Volume

From Greg Fullerton at Affinity Biologicals, Inc. Hi George, I am new to the industry and enjoy reading your site. It gives me a lot of insight into the world of hemostasis. I have two coagulation market related questions for you and a top five list. Hope you can help me out. 1) In your […]

ISTH Lupus Anticoagulant Guidelines

From Kim Kinney at Clarian Health in Indianapolis: Hi George. It was good to see you at the Midwest Hemostasis Symposium this year. My question stems from one of the presentations. There was a presenter from Texas, I believe, who gave a talk on multiple miscarriages. He mentioned that he had been at the recent ISTH meeting […]

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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