ASH 2025 Highlight: Beyond Immunosuppression: Two New Ways to Treat ITP

David Kuter gave this presentation at ASH 2025: Immune thrombocytopenic purpura is now recognized as a disorder characterized by both reduced production and increased destruction—this understanding drives treatment selection toward achieving complete remission, rather than just disease suppression. Increase Platelet Production The latest TPO receptor agonist, hetrombopag, now in phase 3 trials, offers a direct […]

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Bleeding Disorders

Dec 1 2025

george

Let’s Update Hemostasis Test Names

Here is a provocative recommendation from colleague and friend, Dan Kaczor: Hi George, This is the follow-up on the issue of nomenclature posted on 12-1-2025. Although there may be reasons to consider change, as pointed out in the examples given, I believe that we are moving in the wrong direction and are making things difficult […]

Validation

November 2025 QQ Summary: Historic Coag Factor Nomenclature

Our November Quick Question summary about Stuart-Prower Factor, linked to a 2023 article by Dave McGlasson about coagulation factor nomenclature. The summary and McGlasson’s article attracted a comment from Dr. Emmanuel Favaloro, which described the nomenclature of traditional and current VWF activity assays. Dr. Favaloro cited three open-access articles on this topic (click to obtain the […]

Blog

December 2025 Cheat Sheet

Click here to read our December 2025 Cheat Sheet. If you would like a personal “push” Cheat Sheet, please complete the form on the right. Your personal Cheat Sheet includes a complete list of our November entries. Like Fritsma Factor, our Cheat Sheets are free, thanks to Precision BioLogic.

Cheat Sheets

December 2025 Quick Question: Control Proteins

Our December 2025 Quick Question is another quiz, this time about the coagulation control systems. It asks, “What plasma control protein acts against factor IIa (FIIa, thrombin) and factor Xa (FXa, activated FX)? Please answer and add your comment below.

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Quick Question Archive

Nov 28 2025

george

ASH Coagulation Presentation Overview

The 67th ASH Annual Meeting is December 6–9 in Orlando, FL, USA. Here’s Dr. Wolfgang Miesback’s list of bleeding disorder presentations.

Bleeding Disorders

November 2025 QQ Results: Stuart-Prower Factor

Our November 2025 Quick Question asked, “Which is the numeral for the Stuart-Prower factor? Here are the results from our 31 participants: V: 0 (0%0 VII: 3 (10%) X: 19 (61%, correct) XI: 5 (16%) XII: 4 (13%) We scored well. Beginning with the International Committee on Nomenclature’s 1958 recommendations, we began using Roman numerals […]

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Quick Question Archive

Nov 26 2025

george

Response to Low PS Inquiry on Diverse Health Hub

This question was posted on the Diverse Health Hub site (AKA Diagnostic Equity): “Can my birth control pills explain why my protein S level is low at 55%? OR…. should I be evaluated for an actual clotting disorder since low protein S runs in my family?” This comprehensive response was provided by my colleague, LaShanta […]

Thrombophilia

11-8-25 AHA Presentation Records Successful Reduction of Anticoagulation in AFIB

Click here for the results of a “One month of clot prevention after a stent was as effective as a Year-long course for AFIB.” Research Highlights: A one-month course of dual clot-preventing therapy followed by a single clot-prevention medication for the remainder of the standard 12-month regimen in adults with atrial fibrillation (AFib) who received […]

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Anticoagulant Therapy

Nov 19 2025

george

An Illustrated Review of Hemophilia B.

Click here for the illustrated open-access review, Hermans C, Astermark J, Trakymienė SŠ, Jiménez-Yuste, V. Haemophilia B: an illustrative review of current challenges and opportunities. Res Prac Thromb Haemostasis, 2025;9, 103229. Abstract Background Hemophilia B is a genetic bleeding disorder caused by a deficiency of clotting factor IX, which presents unique challenges in clinical management. […]

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Bleeding Disorders

All Posts

ASH 2025 Highlight: Beyond Immunosuppression: Two New Ways to Treat ITP

Let’s Update Hemostasis Test Names

November 2025 QQ Summary: Historic Coag Factor Nomenclature

December 2025 Cheat Sheet

December 2025 Quick Question: Control Proteins

ASH Coagulation Presentation Overview

November 2025 QQ Results: Stuart-Prower Factor

Response to Low PS Inquiry on Diverse Health Hub

11-8-25 AHA Presentation Records Successful Reduction of Anticoagulation in AFIB

An Illustrated Review of Hemophilia B.

George Fritsma MS MLS

Cheat Sheets from George

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