3-MO with prolonged PT and PTT

From “Doctor Mukesh“: a 3 month-old with an old intracranial bleed and an sol has a markedly prolonged prothrombin time (PT) and partial thromboplastin time (PTT) and is bleeding from IV sites but looks pretty alright. What are the possibilities? Hello, and thank you for your question. The PT and PTT reference intervals at three […]

Comments (0)

Bleeding Disorders

Aug 16 2012

george

Establishing PTT Rx Range

From “Kkehoe“: Recognizing that the preferred method for establishing a partial thromboplastin time (PTT) therapeutic range for unfractionated heparin (UFH) is plotting the PTT against the anti-Xa, is there an alternative for labs that don’t perform anti-Xa testing? Are you aware of any commercial kits that can be purchased and used? We currently purchase a […]

Comments (1)

Anticoagulant Therapy

Aug 14 2012

george

Mayo Conference, Cheat Sheet

A big Thank You to everyone who visited the Fritsma Factor booth at the Mayo Laboratories Coagulation Testing Quality conference and exhibit August 7–10 in Rochester, MN, and congratulations to our drawing winners who received either a copy of Rodak BF, Fritsma GA, Keohane EM. Hematology, Clinical Principles and Applications, Elsevier, 2012, or a set of our AACC Press Quick Guides, […]

Cheat Sheets

Specimen Management in Fibrinolysis

I had the opportunity to become reacquainted with Jennifer Jacobsen, MLS (ASCP),Allina Health Laboratories, Minneapolis, while attending the Mayo Laboratories Coagulation Testing Quality conference in Rochester, Minnesota August 7–10. Jennifer has this question about specimen management on patients being treated with tissue plasminogen activator (TPA, Activase®, Alteplase®): George, both the prescribing information for Alteplase and Stago’s fibrinogen reagent package […]

Fibrinolysis

Silica-based PTT Reagent for Factor VIII

From Carol Gizzi at Baycare in Florida, We perform the factor VIII assay with a silica activated APTT ( PTT) reagent. We monitor hemophilic patients. Recently we were asked to switch our reagent to a PTT reagent using ellagic acid as the activator. We do not understand the reason for the request. We thought the silica activated […]

Factor Assays

Validate the Fibrinogen Assay

Because in Romania we don’t have books, guidance or procedures about validation I want to know if for the fibrinogen validation it is necessary to establish the lower limit of detection (LLD) and if the manufacturer does not provide information about the CV% for precision and accuracy what can I do? Best regards, Monica Truta, Clinical […]

Factor Assays

Mixing Studies While on Pradaxa?

From Sara Sneeden, Lee Memorial. Our hematologists are ordering mixing studies on patients who have been on Pradaxa® at home. These patients arrive at the hospital with VMax prothrombin time (PT) and activated partial thromboplastin time (PTT, APTT) and some time later the mixing study is ordered on a subsequent draw. Is there anything to be […]

Mixing Studies

Precision BioLogic and Fritsma Factor at Mayo

We are looking forward to the Mayo Laboratories Coagulation Testing Quality program Tuesday–Friday, August 7–10, 2012 at the Kahler Grand Hotel in Rochester, Minnesota. Precision BioLogic and Fritsma Factor will be booths 19 and 20, respectively, just inside the exhibit’s main entrance. Please be sure to participate in our Fritsma Factor reference book giveaway. We will have ballots […]

Events

Monitoring Heparin with the Anti-Xa assay

From Crystal Azavedo: Hi George, Are you aware of any observation or randomized controlled trial data that compares bleeding and thrombosis risk in patients receiving unfractionated heparin monitored with the activated partial thromboplastin time (aPTT, PTT) compared to monitoring with anti-Xa? In other words, are there clinical outcome data that suggest monitoring with anti-Xa improves patient outcomes? Thanks!! […]

Comments (0)

Anticoagulant Therapy

Jul 29 2012

george

PT Reagents

From Donna Lawler, University of Wisconsin: George, I have been reading with interest the ongoing discussion of PTT reagent selection and enjoyed the corresponding article you cited. I was wondering if you have any similar literature references concerning protime/INR reagents. We use a thromboplastin that has a low ISI (close to 1.0) and good factor sensitivities […]

Comments (0)

Anticoagulant Therapy

All Posts

3-MO with prolonged PT and PTT

Establishing PTT Rx Range

Mayo Conference, Cheat Sheet

Specimen Management in Fibrinolysis

Silica-based PTT Reagent for Factor VIII

Validate the Fibrinogen Assay

Mixing Studies While on Pradaxa?

Precision BioLogic and Fritsma Factor at Mayo

Monitoring Heparin with the Anti-Xa assay

PT Reagents

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question