A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

Here is an open-access review of the genetics of hemostasis: Sabater-Lleal M, Thibord F, de Vries PS, et al. Historical review: more than two decades of understanding the genetic architecture of hemostasis and thrombosis. J Thromb Haemost. 2025:S1538-7836(25)00845-1. doi: 10.1016/j.jtha.2025.11.006. PMID: 41352609. Abstract From the beginning of the millennium and the development of genome-wide analyses, […]

Comments (0)

Coagulation Factors

Jan 24 2026

george

VWD In Women: Non-bleeding Health Issues

Click to read this open-access article that addresses the reproductive, medical, skeletal, psychosocial, and economic impact of VWD in women. Swan D, Sholzberg M, Bannow BS, Thachil J. Von Willebrand disease: more than just a bleeding disorder. Res Pract Thromb Haemost. 2025;10:103276. doi: 10.1016/j.rpth.2025.103276. PMID: 41536292; PMCID: PMC12796595. Abstract Von Willebrand disease (VWD) is the […]

Bleeding Disorders

Diagnostic Equity: PB Platelets in Myelofibrosis

This question appeared on the Diagnostic Equity website on 1-21-2026: “How well do peripheral blood platelet findings correlate with bone marrow fibrosis or megakaryocyte abnormalities in myelofibrosis, and when do lab results suggest a marrow reassessment might be useful?” Diagnostic Equity expert Ryan J. Tom, MS, MLS(ASCP)CM (DCLS Resident) offered this answer: Platelet findings can […]

Comments (0)

Platelet Function Testing

Jan 23 2026

george

Meta-analysis: D-dimer Safely Excludes Pulmonary Embolism in Cancer

Obtain this provocative article from your medical library: Vrotniakaite-Bajerciene K, Mallick R, Takada T, et al. Safety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis. J Thromb Haemost. 2025:S1538-7836(25)00839-6. doi: 10.1016/j.jtha.2025.10.035. PMID: 41354153. Abstract Background: Failure rates of clinical decision […]

Thrombophilia

The Value of Offering DOAC Measurements

Obtain this article from your medical library: Swan D, Roberts L, Thachil J. In a nutshell: testing DOAC levels-when, why and what it means? Br J Haematol. 2026. doi: 10.1111/bjh.70313. PMID: 41482473. Abstract Plasma direct oral anticoagulant (DOAC) levels are not routinely required for the majority of patients; however, they may provide valuable information in […]

Comments (0)

Anticoagulant Therapy

Jan 19 2026

george

Retrospective Comparison of rVWF versus pdVWF During Hospitalization

Here is an open-access article describing the efficacy of vonicog alfa versus plasma-derived VWF: Horvais V, Ternisien C, Denis-Le-Sève J, et al. Vonicog alfa versus plasma-derived von Willebrand factor during hospitalization: results of an observational retrospective multicenter study. Semin Thromb Hemost. 2026. doi: 10.1055/a-2779-9176. PMID: 41529718. Abstract Available products for the treatment of von Willebrand […]

Bleeding Disorders

Case: Thrombocytopenia

In a January 14, 2026 Diagnostic Equity post, an inquirer asked, “I was diagnosed with thrombocytopenia in 2024. I typically just go with the flow of what my doc and the nurse say. What are the lab tests that can help explain why my platelets are low, and how often should my platelets be monitored? […]

Bleeding Disorders

Cohort Study: Do Anticonvulsants Interfere with DOAC Therapy?

Navigate to this open-access population cohort study of the effects of anticonvulsants when used during DOAC Rx: Carlin S, Holbrook AM, Candeloro M, et al. Association of direct oral anticoagulant-anticonvulsant coprescription with clinical outcomes in older adults: a population-based cohort study. J Thromb Haemost. 2025:S1538-7836(25)00727-5. doi: 10.1016/j.jtha.2025.10.027. PMID: 41207565. Abstract Background: Anticonvulsants vary in their […]

Comments (0)

Anticoagulant Therapy

Jan 14 2026

george

Pilot Study: Oxerutin Therapy for Post-thrombotic Syndrome

Select this link to an open-access pilot study describing oxerutin, which is designed to reduce venous blockage after DVT: Iding AFJ, Hupperetz RD, Brans RJB, et al. Additional oxerutin therapy to promote deep vein thrombus resolution (RESOLVE-DVT): a randomized controlled pilot trial. J Thromb Haemost. 2025:S1538-7836(25)00718-4. doi: 10.1016/j.jtha.2025.10.018. PMID: 41197809. Abstract Background: Postthrombotic syndrome (PTS) […]

Thrombophilia

Review: The Effect of Exercise on Bleeding Disorders

This year is the 100th anniversary of the first VWD description, prompting several VWD updates, including Giuffrida AC, Gandini G, Focosi D, Franchini M. Impact of exercise/sport on well-being in von Willebrand disease and other congenital bleeding disorders: an update. Semin Thromb Hemost. 2026. doi: 10.1055/a-2778-9762. PMID: 41512904 available from your medical library. Abstract Worldwide, […]

Comments (0)

Bleeding Disorders

All Posts

A Historical Review: Two Decades of Hemostasis and Thrombosis genetics

VWD In Women: Non-bleeding Health Issues

Diagnostic Equity: PB Platelets in Myelofibrosis

Meta-analysis: D-dimer Safely Excludes Pulmonary Embolism in Cancer

The Value of Offering DOAC Measurements

Retrospective Comparison of rVWF versus pdVWF During Hospitalization

Case: Thrombocytopenia

Cohort Study: Do Anticonvulsants Interfere with DOAC Therapy?

Pilot Study: Oxerutin Therapy for Post-thrombotic Syndrome

Review: The Effect of Exercise on Bleeding Disorders

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question