On-demand HIT Assay

Instrumentation Laboratory announces the July 26, 2016 approval of their HemosIL HIT-Ab(PF4-H) on-demand polyclonal antibody-based latex immunoassay for heparin-induced thrombocytopenia. The assay ifunctions on IL‘s TOP Analyzer series. Attached are IL‘s press release, HIT-Ab(PF4-H) package insert, a 2016 Thrombosis Research article and editorial on the efficacy of on-demand HIT testing. HIT– Ab(PF4-H) Press Release HIT– […]

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Thrombophilia

Aug 11 2016

george

Reversing Plavix with PLT Concentrate

Larry Brace, PhD, Edward Hospital, Naperville, IL. writes that a pathologist is building a protocol to employ platelet concentrate transfusions for reversal of platelet inhibition for patients who are on Plavix or aspirin and are having bleeding or need surgery. He is looking for an objective way to quickly evaluate the status of the platelet […]

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Platelet Function Testing

Jul 21 2016

george

Nijmegen-Bethesda Assay Method

Sarah Payne and Kerri Klemm request information on how to perform the CDC modification of the Nijmegen-Bethesda Assay for coagulation factor inhibitors. Thank both of you for your request, which provides George the opportunity for self-promotion. Please tap or click Coagulation Factor Inhibitors and the Nijmegen Bethesda Assay, a recording of my June 2 digital […]

Bleeding Disorders

CoQ10 and Xarelto

Susequent to our 7/21/16 discussion of Pradaxa’s effect on antiphospholipid antibody testing, Dr. J. S. also asked, “I read where one should not take Co Q-10 if they are on Coumadin (wonder why?). Does the same warning apply to Pradaxa or Xarelto? Thank you for this follow-up question. CoQ10 has antiplatelet properties, as documented in Mortensen […]

Antiplatelet Therapy

Do DOACs Interfere with LAC Testing?

Bonnie Jo Taylor, MHS, MT(ASCP)SH, of Shreveport, LA answers inquiries on the American Society for Clinical Laboratory Science Consumer Web Forum. She and I recently collaborated on this question from Dr. J. S.: “Does Pradaxa anticoagulant Rx affect any of the usual tests for anti-phospholipid antibodies?” Our answer was… Thank you for your question. Yes, Pradaxa […]

Lupus Anticoagulant

Iradukunda Irenee

Visit George’s Facebook page to meet Iradukunda Irenee, (tap here) who graduated July 15, 2016 from the Medical Laboratory Science program on the Kigali, Rwanda campus of Mt. Kenya University. As a student, Irenee ably helped George install laboratory equipment in Kirehe, Rwanda in November, 2014. His MLS program chair in Kigali is Prof. Lawrence Osuwat, […]

Events

Coagulation Assay Protocol

Hello Mr. Fritsma, First of all thank you for taking the time to put together such an informative resource. I have found it very helpful in carryout coagulation tests as part of my master’s thesis in Biomedical Science. I based some of my assays on the procedure found on page https://fritsmafactor.com/post/teaching-mixing-studies and I would like to […]

Mixing Studies

Endothelial Barrier Dysfunction

From Suzanne Gorenfeld: Dear Mr. Fritsma, Are there currently in use any tests to monitor endothelial barrier function during and immediately after surgery? Thank you for your very informative site. Kind regards, Suzanne. Hello, Suzanne, and thank you for your question. This is new territory for me, so I will be looking for help from some of our participants. Meanwhile endothelial barrier […]

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Global Hemostasis Assays

Jul 10 2016

george

Nancy Bergeron

Back to the Precision BioLogic booth at the June 17–18 LABCON exhibit in Charlottetown, with Nancy Bergeron, MA, MLS, from the Faculty of Health Sciences, University of Ontario Institute of Technology.

Events

Weak DRVVT Results

From Tom Exner, Haematek: Hope you had a good 4th of July… Thanks very much for including me sometimes in your interesting online discussions. This time I have an issue on which I would appreciate your advice and possible comments from others if you think it might be suitable for your online interest group. Regarding […]

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Thrombophilia

All Posts

On-demand HIT Assay

Reversing Plavix with PLT Concentrate

Nijmegen-Bethesda Assay Method

CoQ10 and Xarelto

Do DOACs Interfere with LAC Testing?

Iradukunda Irenee

Coagulation Assay Protocol

Endothelial Barrier Dysfunction

Nancy Bergeron

Weak DRVVT Results

George Fritsma MS MLS

Cheat Sheets from George

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