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What is NASCOLA?

I (Geo) enjoyed dining with our NASCOLA colleagues on Wednesday, 7 May 2025, while attending the 2025 ISLH annual meeting in Halifax, NS. NASCOLA is a nonprofit organization that provides proficiency testing services for North American laboratories that perform diagnostic testing for bleeding or thrombotic disorders, thereby improving performance standards. NASCOLA reviews and assists with […]

What is Abelacimab?

In 2020 we posted news about a new DOAC, osocimab, an early and ongoing effort to develop a monoclonal antibody that neutralizes FXI and FXIa. Click here for a press release from Anthos Therapeutics (formerly Blackstone Life Sciences) describing results from the AZALEA-TIMI 71 study that was discontinued early due to an overwhelming reduction in […]

Anticoagulant Therapy

Clotpedia

Click here for Clotpedia, a new (2025) ECAT service developed by Dr. Piet Meijer. Please visit our “Resources” page at your convenience.

Global Organizations Issue Urgent Call to Action

Click here for the ISTH 6 May 2025 Call to Action: Critical Juncture in Hemophilia Treatment. Thanks to Elaine Benoit, Precision BioLogic Inc. for the heads-up. Please post your comments below. From Bob Gosselin, 7 May 2025: This link is more of a political statement than any notion of gene Rx acceptance treatment in HA […]

Bleeding Disorders

May 2025 Cheat Sheet

Here is the May 2025 Cheat Sheet with links to our April entries. Watch for your Cheat Sheet by email. The Cheat Sheet is free, you may get on the mailing list by completing the brief form on the right.

May 2025 Quick Question: Terminology

Our May 2025 Quick Question is a brain teaser inspired by Dave McGlasson’s December 2023 Clot Club entry, Do We Need To Standardize Coagulation Nomenclature In Today’s Laboratory Environment? The question lists several assays that use the letter C. Please select the one that answers, “Which is the routine assay for inflammation?” As always, feel […]

Quick Question Archive

April 2025 QQ Results: Measuring Warfarin in LAC Patients

Our April 2025 Quick Question asked, “How do you measure warfarin in a patient with LAC?” The poll drew 47 respondents and was a sequel to our March 2025 question, “How do you test for lupus anticoagulant?” that referenced the ISTH‘s most recent LAC guideline, Devreese KMJ, Bertolaccini ML, Branch DW, et al. An update […]

Quick Question Archive

Thrombophilia Testing Summary

Click here for a 2025 summary of thrombophilia testing published by the Anticoagulation Forum.

The Choice of Hemophilia Treatments

Here is a brief and informative editorial that lists current hemophilia Rx choices: Makris M, O’Mahony B. Hemophilia treatments and the paradox of choice. Res Pract Thromb Haemost. 2025;9:102726. doi: 10.1016/j.rpth.2025.102726. PMID: 40224276; PMCID: PMC11992418.

Bleeding Disorders

Antithrombin Assay Supports Fitusiran Therapy

Here’s a link to our 1 April 2025 Sanofi announcement about the FDA approval of Fitusiran® therapy. Sanofi provides the Siemens Healthineers’ INNOVANCE Antithrombin® assay, a chromogenic substrate method, as a companion diagnostic tool to support Fitusiran dosing. A Sanofi-supported study compared eight antithrombin activity assay kits on seven coagulometers to indicate the reagent-instrument combinations […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question