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Sep 8 2026
george

Can AI Replace Clinical Prediction Scores in Thrombophilia?

Here is an open-access that compares the efficacy of AI with traditional clinical prediction scores for thrombophilia: Danilatou V, Arachchillage DJ. Beyond accuracy: why replacing traditional scores with AI in thrombosis care creates new ethical and regulatory obligations. Semin Thromb Hemost. 2026 Sep 3. doi: 10.1055/a-2943-7750. PMID: 42692078. Abstract Clinical prediction scores have been central […]
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Thrombophilia
Sep 8 2026
george

Study Results: Novel Thrombin Generation Assay Monitors Emicizumab and Octocog Alfa

Here are the open-access results of a study testing the efficacy of a novel intrinsic trigger reagent (platelet-poor plasma [PPP] Reagent INT) for monitoring emicizumab and octocog alfa: Urlings EH, Heubel-Moenen FCJI, van Oerle R, et al. Intrinsic activated thrombin generation for treatment efficacy and monitoring of octocog alfa and emicizumab in severe hemophilia A. […]
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Bleeding Disorders
Sep 4 2026
george

A Haematologica Review of all Hemophilia Rebalancing Therapy Efforts

Here is an open-access article describing all efforts to develop effective rebalancing therapy, including Latarcibart®, a MOAB that suppresses PS, not previously described in FF:  Van Thillo Q, Hermans C. Rebalancing agents in hemophilia: knowns, unknowns, and uncertainties. Haematologica. 2025 Dec 1;110(12):2902-2912. doi: 10.3324/haematol.2025.288245. PMID: 40820726; PMCID: PMC12666285. Abstract Treatment options for patients with hemophilia […]
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Bleeding Disorders
Sep 4 2026
george

Monitoring ADAMTS13 Deficiency: An Expert Rev. Hematology Review

Here is a current open-access article about ADAMTS13 deficiency: Binder NB, Depasse F, Spannagl M, et al. Clinical laboratory diagnostics and monitoring of ADAMTS13 deficiency and of related diseases: an integrated approach. Expert Rev Hematol. 2026 Sep;19(9):1037-1057. doi: 10.1080/17474086.2026.2702550. PMID: 42461718. Abstract Introduction: ADAMTS13, a crucial enzyme in hemostasis that specifically cleaves von Willebrand factor […]
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Bleeding Disorders
Sep 3 2026
george

Addendum to QQ September 2026: Dr. Favaloro’s Reference

The article cited by Dr. Favaloro in his comment appended to the September 2026 QQ introduction is open access. Click here for the complete text: Favaloro EJ, Pasalic L. Lupus anticoagulant testing during anticoagulation, including direct oral anticoagulants. Res Pract Thromb Haemost. 2022;6:e12676. doi: 10.1002/rth2.12676. PMID: 35316943; PMCID: PMC8922544. Abstract Background Lupus anticoagulants (LA) are […]
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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In your facility, what AC is used for LAC patients with VTE?