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Adjusting AC Volume in Polycythemia

University of Alabama at Birmingham clinical pathologist Chad Siniard MD, shared the following streamlined approach to adjusting the sodium citrate volume to accommodate specimens from patients whose hematocrit exceeds 55%. The formula is adapted from CLSI Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays, 6th ed. Guideline H21, Clinical Laboratory and […]
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June 2024 QQ: Factor Assays

Our June 2025 Quick Question is a poll that asks, “How do you assay factor concentrates?” The question reflects the current hemostasis laboratory efforts to quantify therapeutic FVIII or FIX concentrate activity given the variety of plasma-based, recombinant, B-domain-deleted, and extended half-life therapeutics. We also manage factor concentrates that are employed to control breakthrough bleeds […]
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