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Manual Tilt Tube PT

Here is an open-access editorial commenting on the tilt-tube PT requirement for establishing the reagent thromboplastin ISI. Favaloro EJ. Manual tilt tube method for prothrombin time: a commentary on contemporary relevance. Clin Chem Lab Med. 2025;63:1239–42. doi: 10.1515/cclm-2025-0157. PMID: 39985393.

Screening Assays

Inaccuracies of Venous Thromboembolism Risk Assessment

This April 2025 article indicates a ~29% under-reporting of VTE risk in a cohort of medically ill patients: Lau B, Bhave A, Yui JC, et al. Inaccuracies of venous thromboembolism risk assessment and prevention practices among medically ill patients. Blood Adv. 2025:bloodadvances.2024015306. doi: 10.1182/bloodadvances.2024015306. Epub ahead of print. PMID: 40408310.

Updated DIC Parameters from ISTH

The ISTH SSC Subcommittee on Disseminated Intravascular Coagulation has published its latest definition and scoring system for DIC. Click below for the open-access article. Iba T, Levy JH, Maier CL, et al. Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC Subcommittee on Disseminated Intravascular Coagulation. J Thromb Haemost. […]

Bleeding Disorders

What is PITT?

Click below for an open-access article that classifies VITT and HIT as members of a platelet factor 4 (PF4) disorder, anti-PF4 mediated thrombocytopenia and thrombosis (PITT). Nicolson PLR, Montague SJ, Buka RJ, et al. Anti-PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT-like and VITT-like characteristics. Br J Haematol. 2025. doi: […]

Arterial Thrombosis

Webinar Summarizes ISLH Meeting 7–9 May, 2025

Click here to see our Precision BioLogic Inc. webinar summarizing our activities at the 7–9 May ISLH meeting in Halifax, NS, featuring PBI scientific staff Jon Geske, Ian Burns, Stephanie Henneberry, Mushfigur Rahman, and Tara Quinton. I (Geo) added a presentation describing the NASCOLA meeting. NASCOLA typically schedules its annual meeting to coincide with major […]

COVID-Coag Information

Early in 2021 Fritsma Factor published a narrated 40-minute PowerPoint file named COVID-Coag. While it may seem dated, the presentation links the SARS-Cov19 virus to acute inflammation, platelet activation, DIC, SIC, TMA, TTP, and VITT (recently categorized as “PITT“), insights born of our intense studies of the pandemic. Further, this article appears in the April […]

Agent Orange

This entry was in response to a question from Dennis Brondi: “Hi–I was exposed to Agent Orange and have primary APS (also single parent factor V Leiden). Do you know of any studies establishing causation between AO and APS? My issues have included avascular necrosis of both femoral heads and multiple large DVTs from the […]

Bleeding Disorders

Bleeding Time

I (Geo) received this question on May 23, 2025: “I am using 100 mg of aspirin and 75 mg of Plavix. My PTT is 35.8 seconds; PT 13.8 seconds, INR 1.18; bleeding time is 1 minute and 30 seconds; clotting time is 8 minutes. Are these results normal when using the two drugs together?” I […]

Antiplatelet Therapy

June 2025 Cheat Sheet

Click here to download your June 2025 Cheat Sheet. The Cheat Sheet links you to our May 2025 entries and before. Your personal Cheat Sheet will arrive in your email box 2–5 June. If you are not received the “push” edition of the Cheat Sheet, please fill out the form on the right and we […]

June 2025 Quick Question: Fibrinolysis

Our June 2025 Quick Question asks, Which fibrinolysis component directly digests fibrin? Please find the question on the right side of the “Posts” menu and make your selection. As always, we invite your comments using the function below.

Quick Question Archive

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

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