Poor old aspirin has again lost ground. Here’s an editorial from the January, 2019 issue of European Heart Journal describing a meta-analysis of aspirin’s lack of efficacy in subjects who have no cardiovascular disease risk factors:
The meta-analysis, available from the European Heart Journal site, is Mahmoud AN, Gad MM, Elgendyi Ay, et al. Efficacy and safety of aspirin for primary
prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials. Eur Heart J 2019: 40, 607–17.
Participants, why do you think this new analysis contradicts the overwhelmingly positive results of the Physician Health Study and the Women’s Health Study of the 1980s and 1990s?