β2GP1: β2 glycoprotein 1
11DOHTXB2: 11-dehydrothromboxane B2
11DOH: 11-dehydrothromboxane B2
AABB: Association for the Advancement of Blood & Biotherapies (formerly Am Assn of Blood Banks)
ABR: Annual bleed rate
AC: Anticoagulant
ACA: Anti-cardiolipin antibody (also ACL)
ACL: Anti-cardiolipin antibody (also ACA)
ACT: Activated clotting time assay
ADAMTS13: A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13
ADLM: Association for Diagnostics and Laboratory Medicine (formerly AACC)
ADP: Adenosine diphosphate
AF: Atrial fibrillation
AFIB: Atrial fibrillation
AMI: Acute myocardial infarction
AMR: Analytical measurement range
anti-Xa: Chromogenic anti-Xa anticoagulant assay
API: American Proficiency Institute, provides external quality assurance services
APC: Activated protein C
APCR: Activated protein C resistance
APL: Anti-phospholipid antibody
APTT: Activated partial thromboplastin time, partial thromboplastin time
ARU: Aspirin resistance unit
ASA: Aspirin; acetyl salicylic acid
ASCLS: American Society for Clinical Laboratory Science
AT: Antithrombin or antithrombin III (obsolete)
ATIII: Antithrombin III (obsolete) or antithrombin
ASD: Atrial septal defect
ATP: Adenosine triphosphate
BDD: B-domain-deleted
BMJ: British Medical Journal
BSS: Bernard-Soulier syndrome
BT: Bleeding time
BU: Bethesda units
CABG: Coronary artery bypass graft
CAP: College of American Pathologists; provides external quality assurance services
CAPS: Catastrophic antiphospholipid syndrome
CBC: Complete blood count
CDC: US Centers for Disease Control and Prevention
CFX: Chromogenic factor X assay
CLIA: Clinical Laboratory Improvement Amendments
CLIAC: Clinical Laboratory Improvement Advisory Committee
CLL: Chronic lymphocytic leukemia
CLSI: Clinical and Laboratory Standards Institute
COX: Cyclooxygenase
COX-1: Cyclooxygenase-1
COX-2: Cyclooxygenase-2
CRP: C-reactive protein, an inflammation marker
CSA: Two-stage chromogenic substrate factor assay
CT: Computed tomography
CVA: Cerebrovascular accident
D-D: D-dimer
DAPT: Dual antiplatelet therapy
DDAVP: Desamino-8-D-arginine vasopressin, desmopressin
DIC: Disseminated intravascular coagulation
DOAC: Direct oral anticoagulant therapeutic
DRVVT: Dilute Russell viper venom time
DTI: Direct thrombin inhibitor
DTS: Dense tubular system
DVT: Deep venous thrombosis
EC: Endothelial cell
ECA: Stago’s Ecarin Chromogenic Assay
ECAT: European Concerted Action on Thrombosis (ECAT Foundation), provides the External Quality Assessment Programme (EQAP)
ECMO: Extra-corporeal membrane oxygenation
ECT: Ecarin clotting time
ED: Emergency department, emergency room, erectile dysfunction
EHL: Extended half-life
EIA: Enzyme immunoassay
ELISA: Enzyme-linked immunosorbent assay
ELT: Euglobulin lysis time
EQAP: External Quality Assessment Programme
ER: Emergency room, emergency department
EUA: FDA emergency use authorization
ESRD: End-stage renal disease
FB: Fibroblast
FBG: Fibrinogen
Fc: The “fragment crystallizable” antibody region that interacts with cell surface receptors called Fc receptors.
FDA: US Food and Drug Administration
FDP: Fibrin (ogen) degradation products
FEIBA: Factor VIII inhibitor bypassing activity
FFP: Fresh frozen plasma
Fg: Fibrinogen
FII: Factor II, prothrombin
FIIa: Activated factor II, thrombin
FIX: Factor IX
FP24: 24-hour frozen plasma
FRET: Fluorescence resonance energy transfer
FSP: Fibrin (ogen) split products
FVIII: Factor VIII
FVIII:C: Factor VIII coagulant activity
FVIIIR:Ag: Factor VIII-related antigen (VWF-related antigen)
FVL: Factor V Leiden mutation
g/dL: Grams per deciliter
GP Ib: Glycoprotein Ib
GP IIb: Glycoprotein IIb
GP IIb/IIIa: Glycoprotein IIb/IIIa
GP IX: Glycoprotein IX
GP V: Glycoprotein V
GT: Glanzmann thrombasthenia
HA: Hemophilia A (FVIII deficiency)
HB: Hemophilia B (FIX deficiency)
Hb: Hemoglobin, HGB
HCT: Hematocrit
HCY: Homocysteine
HGB: Hemoglobin, Hb
HIT: Heparin-induced thrombocytopenia with thrombosis
HITT: Heparin-induced thrombocytopenia with thrombosis
HMWK: High molecular weight kininogen (Fitzgerald factor)
HPA: Human platelet antigen
HRT: Hormone replacement therapy
HUS: Hemolytic-uremic syndrome
Hx: History
H&P: History & physical
ICH: Intracranial hemorrhage
ICSH: International Council for Standardization in Haematology
IFU: Instructions for use
IJLH: International Journal of Laboratory Hematology
IL: Interleukin
IM: Intramuscular
INR: International normalized ratio
IPA: Isopropyl alcohol
IRP: International reference preparation
ISI: International sensitivity index
ISLH: International Society for Laboratory Hematology
ISTH: International Society on Thrombosis and Haemostasis
ITP: Immune thrombocytopenic purpura
IV: Intravascular
IVD: In vitro diagnostics
IVIg: Intravenous immunoglobulin
JACC: Journal of the American College of Cardiology
LA: Lupus anticoagulant
LAC: Lupus anticoagulant
LDT: Lab-developed test (“home-grown”)
LIA: Latex immunoassay
LLOD: Lower limit of detection
LMWH: Low molecular weight heparin
LVAD: Left ventricular assist device
mg/dL: Milligrams per deciliter
MGUS: Monoclonal gammopathy of unknown significance
MNPT: Mean normal prothrombin time
MPN: Myeloproliferative neoplasm
MGTS: Monoclonal gammopathy of thrombotic significance
MRI: Mean of the reference interval, magnetic resonance imaging
MVA: Microvascular angina
NASCOLA: North American Specialized Coagulation Laboratory Association
NATP: Neonatal alloimmune thrombocytopenic purpura
ng/mL: Nanograms per milliliter
NBU: Nijmegen Bethesda unit
NET: Neutrophil extracellular trap
NO: Nitric oxide
NP: Normal plasma
NSAID: Non-steroidal anti-inflammatory drug
NVAF: Non-valvular atrial fibrillation
OC: Oral contraceptive
OAC: Oral anticoagulant
OCR: Oral contraceptive
OCS: Open canalicular system
OSA: One-stage clot-based factor assay
PAD: Peripheral artery disease, peripheral artery occlusion
PAI-1: Plasminogen activator inhibitor-1
PAO: Peripheral artery occlusion, peripheral artery disease
PC: Protein C
PCC: Prothrombin complex concentrate
PCI: Percutaneous coronary intervention
PCP: Primary care physician
PCR: Polymerase chain reaction
PE: Pulmonary embolism
PECAM: Platelet-endothelial cell adhesion molecule
PF 1+2: Prothrombin fragment 1+2
PF 1.2: Prothrombin fragment 1.2
PF4: Platelet factor 4
PFA: Platelet function analyzer
PFP: Platelet-free plasma
PG: Prostaglandin
PITT: Anti-PF4 mediated thrombocytopenia and thrombosis
PIVKA: Proteins in vitamin K antagonism
PK: Prekallikrein (Fletcher factor), pharmacokinetics
PL: Phospholipid
PLA: Human platelet antigen
PLC: Phospholipase C
PLEX: Plasma exchange
PLT: Platelet
PNP: Pooled normal plasma
POC: Point of care
PPP: Platelet-poor plasma
PRP: Platelet-rich plasma
PS: Protein S
PT: Prothrombin time (protime)
PT/INR: Prothrombin time with international normalized ratio
PTR: Prothrombin time ratio
PTs: Prothrombin time (protime)
PTT: Partial thromboplastin time, activated partial thromboplastin time
PTTs: Partial thromboplastin times
RBC: Red blood cell
rFVIII: Recombinant FVIII concentrate
rFIX: Recombinant FIX concentrate
RI: reference interval, “normal range”
RIPA: Ristocetin-induced platelet aggregation
RNA: Ribonucleic acid
RNAi: RNA inhibitor
ROC: Receiver-operating characteristic
ROTEM: Rotational thromboelastometry
RUO: Research use only
RVVT: Russell viper venom time
Rx: Prescription, therapeutic
SAK: Staphylokinase
SC: Subcutaneous, subcutaneously
SERPIN: Serine protease inhibitor
SIC: Sepsis-induced coagulopathy
SK: Streptokinase
SMC: Smooth muscle cell
SOFA: Sequential organ failure assessment
SOP: Standard operating protocol (procedure)
SPRCA: Solid-phase red blood cell agglutination assay
STH: Seminars in Thrombosis and Hemostasis
SQ: Subcutaneous
TAFI: Thrombin-activated fibrinolysis inhibitor
TAT: Thrombin-antithrombin
TCT: Thrombin clotting time
TEG: Thromboelastograph, thromboelastography
TEM: Rotational thromboelastometry
TF: Tissue factor
TIA: Transient ischemic attack
TM: Thrombomodulin
TMA: Thrombotic microangiopathy
TNF: Tumor necrosis factor
TPA: Tissue plasminogen activator
TT: Thrombin clotting time
TTI: Tissue thromboplastin inhibition
TTP: Thrombotic thrombocytopenic purpura
TTR: Time in therapeutic range
TXA2: Thromboxane A2
TXB2: Thromboxane B2
UA: Unstable angina
UFH: Unfractionated (standard) heparin
UK: Urokinase
USPI: United States Prescribing Information
VET: Viscoelastometry (thromboelastometry)
VITT: Vaccine-induced immune thrombotic thrombocytopenia
VK: Vitamin K
VKA: Vitamin K antagonist
VTE: Venous thromboembolism
VWD: von Willebrand disease
VWF: von Willebrand factor
VWF:Act: von Willebrand factor activity
VWF:Ag: von Willebrand factor antigen
VWF:CB: von Willebrand factor collagen binding activity
VWFCP: von Willebrand factor cleaving protease (ADAMTS13)
VWF:Gp1bR: Ristocetin-triggered nonplatelet GPIb-based activity assay
VWF:Gp1bM: Gain-of-function high-affinity recombinant GPIb activity assay
VWF:RCo: von Willebrand factor ristocetin cofactor activity
WBC: White blood cell
YO: Year-old, years of age
YOA: Years of age
