List of abbreviations and definitions
β2GP1: β2 glycoprotein 1
11DOHTXB2: 11-dehydrothromboxane B2
11DOH: 11-dehydrothromboxane B2
AABB: Association for the Advancement of Blood & Biotherapies (formerly American Association of Blood Banks)
ABR: Annual Bleed Rate
ACA: Anti-cardiolipin antibody (also ACL)
ACL: Anti-cardiolipin antibody (also ACA)
ACT: Activated clotting time assay
ADAMTS13: A disintegrin & metalloproteinase with a thrombospondin type 1 motif, member 13 (also VWF-cleaving protease)
ADLM: Association for Diagnostics and Laboratory Medicine (formerly AACC)
ADP: Adenosine diphosphate
AF: Atrial fibrillation
AFIB: Atrial fibrillation
AMI: Acute myocardial infarction
anti-Xa: Chromogenic anti-Xa anticoagulant assay
APC: Activated protein C
APCR: Activated protein C resistance
APL: Anti-phospholipid antibody
APTT: Activated partial thromboplastin time, partial thromboplastin time
ARU: Aspirin resistance unit
ASA: Aspirin; acetyl salicylic acid
ASCLS: American Society for Clinical Laboratory Science
AT: Antithrombin or antithrombin III
ATIII: Antithrombin III or antithrombin
ATP: Adenosine triphosphate
BMJ: British Medical Journal
BSS: Bernard-Soulier syndrome
BT: Bleeding time
BU: Bethesda units
CABG: Coronary artery bypass graft
CAPS: Catastrophic antiphospholipid syndrome
CBC: Complete blood count
CDC: US Centers for Disease Control and Prevention
CLIA: Clinical Laboratory Improvement Amendments
CLIAC: Clinical Laboratory Improvement Advisory Committee
CLL: Chronic lymphocytic leukemia
COX: Cyclooxygenase
COX-1: Cyclooxygenase-1
COX-2: Cyclooxygenase-2
CSA: Two-stage chromogenic substrate factor assay
CVA: Cerebrovascular accident
D-D: D-dimer
DAPT: Dual anti-platelet therapy
DDAVP: Desamino-8-D-arginine vasopressin, desmopressin
DIC: Disseminated intravascular coagulation
DOAC: Direct oral anticoagulant
DRVVT: Dilute Russell viper venom time
DTI: Direct thrombin inhibitor
DTS: Dense tubular system
DVT: Deep venous thrombosis
EC: Endothelial cell
ECA: Stago’s Ecarin Chromogenic Assay
ECMO: Extra-corporeal membrane oxygenation
ECT: Ecarin clotting time
ED: emergency department, emergency room
EIA: Enzyme immunoassay
ELISA: Enzyme-linked immunosorbent assay
ELT: Euglobulin lysis time
ER: Emergency room, emergency department
ESRD: End-stage renal disease
EUA: FDA emergency use authorization
FB: Fibroblast
FBG: Fibrinogen
FDA: US Food and Drug Administration
FDP: Fibrin (ogen) degradation products
FEIBA: Factor VIII inhibitor bypassing activity
FFP: Fresh frozen plasma
Fg: Fibrinogen
FP24: 24-hour frozen plasma
FSP: Fibrin (ogen) split products
FVIII: Factor VIII
FVIII:C: Factor VIII coagulant activity
FVIIIR:Ag: Factor VIII-related antigen (VWF-related antigen)
FVL: Factor V Leiden mutation
g/dL: Grams per deciliter
GPIb: Glycoprotein Ib
GPIIb: Glycoprotein IIb
GPIIb/IIIa: Glycoprotein IIb/IIIa
GP IX: Glycoprotein IX
GP V: Glycoprotein V
GT: Glanzmann thrombasthenia
Hb: Hemoglobin, HGB
HCT: Hematocrit
HCY: Homocysteine
HGB: Hemoglobin, Hb
HIT: Heparin-induced thrombocytopenia with thrombosis
HITT: Heparin-induced thrombocytopenia with thrombosis
HMWK: High molecular weight kininogen (Fitzgerald factor)
HPA: Human platelet antigen
HRT: Hormone replacement therapy
HUS: Hemolytic uremic syndrome
ICH: Intracranial hemorrhage
IFU: Instructions for use
IL: Interleukin
IM: Intramuscular
INR: International normalized ratio
IPA: Isopropyl alcohol
IRP: International reference preparation
ISI: International sensitivity index
ISLH: International Society for Laboratory Hematology
ISTH: International Society on Thrombosis and Haemostasis
ITP: Immune thrombocytopenic purpura
IV: Intravascular
IVIg: Intravenous immunoglobulin
JACC: Journal of the American College of Cardiology
LA: Lupus anticoagulant
LAC: Lupus anticoagulant
LDT: Laboratory-developed test
LIA: Latex immunoassay
LMWH: Low molecular weight heparin
LVAD: Left ventricular assist device
mg/dL: Milligrams per deciliter
MNPT: Mean normal prothrombin time
MPN: Myeloproliferative neoplasm
MRI: Mean of the reference interval
NASCOLA: North American Specialized Coagulation Laboratory Association
NATP: Neonatal alloimmune thrombocytopenic purpura
ng/mL: Nanograms per milliliter
NBU: Nijmegen Bethesda units
NO: Nitric oxide
NP: Normal plasma
NSAID: Non-steroidal anti-inflammatory drug
NVAF: Non-valvular atrial fibrillation
OC: Oral contraceptive
OCR: Oral contraceptive
OCS: Open canalicular system
OSA: One-stage clot-based factor assay
PAD: Peripheral artery disease, peripheral artery occlusion
PAI-1: Plasminogen activator inhibitor-1
PAO: Peripheral artery occlusion, peripheral artery disease
PC: Protein C
PCC: Prothrombin complex concentrate
PCI: Percutaneous coronary intervention
PCR: Polymerase chain reaction
PE: Pulmonary embolism
PECAM: Platelet-endothelial cell adhesion molecule
PF1+2: Prothrombin fragment 1+2
PF1.2: Prothrombin fragment 1.2
PF4: Platelet factor 4
PFA: Platelet function analyzer
PFP: Platelet-free plasma
PG: Prostaglandin
PIVKA: Proteins in vitamin K antagonism
PK: Prekallikrein (Fletcher factor)
PL: Phospholipid
PLA: Human platelet antigen
PLC: Phospholipase C
PLT: Platelet
PNP: Pooled normal plasma
POC: Point of care
PPP: Platelet-poor plasma
PRP: Platelet-rich plasma
PS: Protein S
PT: Prothrombin time (protime)
PT/INR: Prothrombin time with international normalized ratio
PTR: Prothrombin time ratio
PTT: Partial thromboplastin time, activated partial thromboplastin time
RBC: Red blood cell
RI: Reference interval, “normal range”
RIPA: Ristocetin-induced platelet aggregation
RNA: Ribonucleic acid
ROC: Receiver-operating characteristic
ROTEM: Rotational thromboelastometry
RVVT: Russell viper venom time
SAK: Staphylokinase
SC: Subcutaneous, subcutaneously
SERPIN: Serine protease inhibitor
SK: Streptokinase
SMC: Smooth muscle cell
SPRCA: Solid-phase red blood cell agglutination assay
SQ: Subcutaneous
TAFI: Thrombin-activatable fibrinolysis inhibitor
TAT: Thrombin-antithrombin
TCT : Thrombin clotting time
TEG: Thromboelastograph, thromboelastography
TEM: Rotational thromboelastometry
TF: Tissue factor
TIA: Transient ischemic attack
TM: Thrombomodulin
TMA: Thrombotic microangiopathy
TNF: Tumor necrosis factor
TPA: Tissue plasminogen activator
TCT: Thrombin clotting time
TT: Thrombin clotting time
TTI: Tissue thromboplastin inhibition
TTP: Thrombotic thrombocytopenic purpura
TTR: Time in therapeutic range
TXA2: Thromboxane A2
TXB2: Thromboxane B2
UA: Unstable angina
UFH: Unfractionated (standard) heparin
UK: Urokinase
VET: Viscoelastometry (thromboelastography)
VK: Vitamin K
VKA: Vitamin K antagonist
VTE: Venous thromboembolism
VWD: von Willebrand disease
VWF: von Willebrand factor
VWF:Ac: von Willebrand factor activity
VWF:Ag: von Willebrand factor antigen
VWF:CB: von Willebrand factor collagen binding activity
VWFCP: von Willebrand factor cleaving protease (ADAMTS13)
VWF:Gp1bR: Ristocetin-triggered nonplatelet GPIb-based activity assay
VWF:Gp1bM: Gain-of-function high-affinity recombinant GPIb activity assay
VWF:RCo: von Willebrand factor ristocetin cofactor activity
WBC: White blood cell
YO: year-old, years of age
YOA: Years of age
