Zontivity (vorapaxar)

Zontivity (vorapaxar)
Aug 28, 2019 8:42am

I'm curious about how many of our participants monitor vorapaxar (Zontivity®, New American Therapeutics, Inc) antiplatelet therapy. Vorapaxar is the only protease-activated receptor-1 (PAR-1) antagonist that reduces thrombotic cardiovascular events in patients with a history of myocardial infarction or peripheral arterial disease, FDA-approved in 2014. Vorapaxar is used alongside dual antiplatelet therapy (aspirin and clopidogrel; aspirin and ticagrelor) and fully suppresses thrombin receptor agonist peptide (TRAP)-induced platelet aggregation after one week of treatment. Upon discontinuation, the antiplatelet effect measured by TRAP aggregometry lasts at least four weeks. Vorapaxar does not affect ADP , collagen, or arachidonic acid-induced aggregation, and does not affect coagulation parameters. Please add your comments here or email to george@fritsmafactor.com.

0 Comments

I'm curious about how many of our participants monitor vorapaxar (Zontivity®, New American Therapeutics, Inc) antiplatelet therapy. Vorapaxar is the only protease-activated receptor-1 (PAR-1) antagonist that reduces thrombotic cardiovascular events in patients with a history of myocardial infarction or peripheral arterial disease, FDA-approved in 2014. Vorapaxar is used alongside dual antiplatelet therapy (aspirin and clopidogrel; aspirin and ticagrelor) and fully suppresses thrombin receptor agonist peptide (TRAP)-induced platelet aggregation after one week of treatment. Upon discontinuation, the antiplatelet effect measured by TRAP aggregometry lasts at least four weeks. Vorapaxar does not affect ADP , collagen, or arachidonic acid-induced aggregation, and does not affect coagulation parameters. Please add your comments here or email to george@fritsmafactor.com.

Leave A Comment

You must be logged in to Comment - Sign In