Posts - Mixing Studies

Dec 17, 2017 10:44am
A colleague recently contacted George about prothrombin time mixing studies. Apparently, the College of American Pathologists provided a PT mixing study challenge in a recent survey. George discussed PT
Nov 16, 2017 7:23am
From Jasmina, Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh India
Nov 8, 2017 4:11pm
From "Ari." Hi George, I stumbled upon your amazing site when researching this question and was wondering if you could shed some light on this. I have a patient who had a DVT. His PCP noted a slightly prolonged aPTT and sent mixing studies. From what I can tell, the aPTT mostly corrected with mix, but the PTT-LA is definitely long and only slightly corrects (basically it stays prolonged). I understand the PTT-LA results as indicative of a lupus anticoagulant (LAC ) which fits the clinical picture of DVT , but I'm having trouble understanding why the aPTT would correct on mixing. Can you shed some light on this? I've copied the relevant labs with patient identifying factors removed to this link: (Readers go to the link for the patient data, Geo.)
1 Comment
Oct 4, 2017 9:26pm
A message from Rose Markarian, Providence Health & Services: What is the purpose of incubating pooled normal plasma (NP ) separately and the patient's plasma separately for 60 minutes? Then after 60 minutes of incubation you mix them together and run to get a PTT and this is labeled as control tube. Please explain!