A pre-publication article, Young G, Perry D, The International Prophylaxis Study Group (IPSG). Laboratory assay measurement of modified clotting factor concentrates: a review of the literature and recommendations for practice. J Thromb Haemostas pre-publication, 1-22-19 provides advice on how to measure extended half-life and B-domain-deleted factor concentrates VIII and IX. The article illustrates the wide variations in PTT-based one-stage clot-based assay results for the various new preparations related to the various reagent activators silica, kaolin, ellagic acid, or polyphenols. The writers show that the currently available chromogenic substrate factor VIII assays recover reasonably accurate results for all preparations. Chromogenic factor IX assays are approved for use in only a handful of locations but provide accurate measurement of factor IX concentrate therapy.
Posts - Coagulation Factors
Jan 30, 2019 7:53am
Jan 27, 2019 11:35am
George has attached Anne Paxton's article, Navigating the Quandaries of Coagulation Testing, (click or tap) featuring Drs. Michael Laposata, Dot Adcock, and Kristi Smock. The article features the need for laboratory-clinician communication.
Oct 2, 2018 6:05am
Our September, 2018 Quick Question was a quiz with one correct answer addressing our knowledge of the coagulation cascade: Which coagulation factor is the first activated in the extrinsic pathway? With 144 responding, the answers were: Factor XII: 16 (11%) Factor IX: 9 (6%) Factor VII: 105 (73%) Prothrombin: 14 (10%)