Is APS Hereditary?

Is APS Hereditary?
Apr 22, 2017 7:40am

An intriguing case from Heather DeVries, Indiana University Health.

Hi George, I have an interesting (cold) case study for you. We recently tested a 44 yo female for lupus antibodies and she had textbook results--nothing equivocal about them. Her history includes a late-term pregnancy loss 12 years ago, and a recent diagnosis of lupus, so it seems that she could now be considered to have antiphospholipid antibody syndrome (APS). This is where the family history comes in.

Her maternal grandmother had a stroke while pregnant with her third child in her 30s, and another in her 70s that was ultimately fatal. There was never an explanation for the stroke during pregnancy.  Is it possible that she had undetected antiphospholipid antibodies? I have never seen anything about them being hereditary, and would love to hear any thoughts/opinions from the coag community. Thanks, Heather

From George, Hi, Heather, and thank you for this case. I started to belittle the idea that APS could be hereditary, or could have a familial distribution, however a quick PubMed search turned up this, the most recent of several articles that connect APS with HLA system antigens:

Sebastiani GD, Iuliano A, Cantarini L, Galeazzi M. Genetic aspects of the antiphospholipid syndrome: An update.. Autoimmun Rev. 2016;15:433–9.
Abstract
Studies on the immunogenetic predisposition to antiphospholipid syndrome (APS) and on other non-genetic and epigenetic factors are summarised and discussed. Family studies suggest a genetic predisposition to APS. It appears that this genetic predisposition is in part accounted for by the HLA system, the most consistent associations being those with DR4 and DRw53. Furthermore, it appears that lupus anticoagulant (LA ) and anticardiolipin (aCL ) antibodies are both associated with the same HLA antigens. Population studies suggest that HLA genes have a role in conferring susceptibility to develop primary APS, with some differences in different ethnic groups. Other genes, outside the MHC, give their contribution to the development of this autoimmune syndrome, such as IRF5, STAT4 and those related to inherited thrombophilia--factor V Leiden and G20210A prothrombin polymorphisms. Finally, post-transcriptional modifications of anti-beta2GPI antibodies could be implicated too.

 

4 Comments

An intriguing case from Heather DeVries, Indiana University Health.

Hi George, I have an interesting (cold) case study for you. We recently tested a 44 yo female for lupus antibodies and she had textbook results--nothing equivocal about them. Her history includes a late-term pregnancy loss 12 years ago, and a recent diagnosis of lupus, so it seems that she could now be considered to have antiphospholipid antibody syndrome (APS). This is where the family history comes in.

Her maternal grandmother had a stroke while pregnant with her third child in her 30s, and another in her 70s that was ultimately fatal. There was never an explanation for the stroke during pregnancy.  Is it possible that she had undetected antiphospholipid antibodies? I have never seen anything about them being hereditary, and would love to hear any thoughts/opinions from the coag community. Thanks, Heather

From George, Hi, Heather, and thank you for this case. I started to belittle the idea that APS could be hereditary, or could have a familial distribution, however a quick PubMed search turned up this, the most recent of several articles that connect APS with HLA system antigens:

Sebastiani GD, Iuliano A, Cantarini L, Galeazzi M. Genetic aspects of the antiphospholipid syndrome: An update.. Autoimmun Rev. 2016;15:433–9.
Abstract
Studies on the immunogenetic predisposition to antiphospholipid syndrome (APS) and on other non-genetic and epigenetic factors are summarised and discussed. Family studies suggest a genetic predisposition to APS. It appears that this genetic predisposition is in part accounted for by the HLA system, the most consistent associations being those with DR4 and DRw53. Furthermore, it appears that lupus anticoagulant (LA ) and anticardiolipin (aCL ) antibodies are both associated with the same HLA antigens. Population studies suggest that HLA genes have a role in conferring susceptibility to develop primary APS, with some differences in different ethnic groups. Other genes, outside the MHC, give their contribution to the development of this autoimmune syndrome, such as IRF5, STAT4 and those related to inherited thrombophilia--factor V Leiden and G20210A prothrombin polymorphisms. Finally, post-transcriptional modifications of anti-beta2GPI antibodies could be implicated too.

 

By Technical Specialist Heather DeVries
Apr 22, 2017 12:26pm
That is great information, George. Thank you!!
By Dr. Vadim Kostousov
Apr 27, 2017 6:20pm
Full text of another paper is available here:

Goel N, et. al. Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance. Arthritis Rheum. 1999;42:318–27.
http://onlinelibrary.wiley.com/doi/10.1002/1529-0131(199902)42:2%3C318::AID-ANR15%3E3.0.CO;2-5/pdf
By Technical Specialist Heather DeVries
May 6, 2017 1:26pm
The autosomal dominance is interesting. Less likely to skip a generation if so?
Makes sense to me (Geo).
By Clinical Research Scientist David McGlasson
May 10, 2017 10:06pm
To all. The following abstract on familial association was presented in 1992. Yes I believe it exists.
Berdeaux DH, McGlasson DL, Marlar RA. Familial association of antiphospholipid antibodies in index patients with primary antiphospholipid syndrome. Blood 1992;80, Suppl 1.

Leave A Comment

You must be logged in to Comment - Sign In