APL Positivity Cutoffs: 99th Percentile?

For a fresh look at anticardiolipin antibody and anti-β2-GP1 analysis decision points, click Anunciación-Llunell A, Marques-Soares J, Ockova M, et al. The absence of standardization in antiphospholipid antibody testing may favor the use of 99th percentile cutoffs in antiphospholipid syndrome classification. Res Pract Thromb Haemost. 2025;9:102967. doi: 10.1016/j.rpth.2025.102967. PMID: 40761700; PMCID: PMC12320162.

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Thrombophilia

Aug 27 2025

george

World Thrombosis Day Campaign: Note From Samantha Nelson, WTD Manager

Dear George, The International Society on Thrombosis and Haemostasis (ISTH) World Thrombosis Day (WTD) campaign is in its 12th year, and together with The Fritsma Factor, Your Interactive Hemostasis Resource, we have been working to build awareness around a critical reality: 1 in 4 people worldwide die each year from conditions related to thrombosis. This […]

Thrombophilia

World Thrombosis Day 2025

It’s time to be thinking about World Thrombosis Day. From the WTD site, “World Thrombosis Day, founded by the International Society on Thrombosis and Haemostasis (ISTH), is a global initiative held annually on October 13. Our mission is to raise awareness about thrombosis, a condition often underestimated and misunderstood. Your participation can help inspire positive […]

Thrombophilia

Thrombotic Thrombocytopenic Purpura

Click “In Their Blood” for a review article about TTP from the University of Kansas (KU) Medical Center’s Pathology Department. The article highlights the early research into ADAMTS13‘s role in VWF metabolism, the early successes of PLEX therapy, and the current availability of the therapeutics caplacizumab and the ADAMTS13 concentrate, Adzynma. Also featured is the […]

Bleeding Disorders

August 2025 QQ: Anticoagulant Choice for AFIB

Our August 2025 Quick Question asks, “What AC does your provider prescribe for non-valvular AFIB?” I (Geo) asked my PCP this question at my annual wellness visit on July 29, 2025. Not a personal concern, just curious. Please provide your answer on the right and add your comments, which will appear in our end-of-month summary.

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Quick Question Archive

Jul 22 2025

george

Postpartum DIC

Check with your medical library for this review, dated 7-18-25. Wolfovitz A, Brenner B, Solt I. Postpartum disseminated intravascular coagulation: A comprehensive review of pathophysiology, diagnosis, management, and prevention. Semin Thromb Hemost. doi: 10.1055/a-2645-2845. Epub ahead of print. PMID: 40680793. Abstract Disseminated intravascular coagulation (DIC) in the postpartum period is a rare but potentially life-threatening […]

Fibrinolysis

What is Monoclonal Gammopathy of Thrombotic Significance?

Just when we thought there was nothing new in hemostasis, the June 2025 CAP Today front-page article by Karen Titus, Spectrum of Anti-PF4 Disorders Widens, ties together HITT, VITT, and what we have known as commonplace MGUS, here renamed MGTS, all fit together in the category, anti-PF4 disorders. I (Geo) recommend this excellent article that […]

Thrombophilia

DIC Update

On Monday, June 23, Ecaterina (Katy) Scarlatescu, MD, PhD, Department of Anaesthesia and Intensive Care, Fundeni Clinical Institute, University of Medicine and Pharmacy, Bucharest, Romania, chaired a plenary session of panelists at the ISTH annual meeting in Washington, DC, USA. The panel discussed the 2025 ISTH DIC definition and diagnostic guidelines we reported on June […]

Thrombophilia

Invent-VTE

In the ISTH annual meeting (June 21–25, 2025) I (Geo) met a representative of Invent-VTE, a non-profit dedicated to fostering international VTE research collaboration. Navigate to Hemostasis Agencies to see Invent-VTE‘s website and our complete list of hemostasis-related agencies.

Events

Inaccuracies of Venous Thromboembolism Risk Assessment

This April 2025 article indicates a ~29% under-reporting of VTE risk in a cohort of medically ill patients: Lau B, Bhave A, Yui JC, et al. Inaccuracies of venous thromboembolism risk assessment and prevention practices among medically ill patients. Blood Adv. 2025:bloodadvances.2024015306. doi: 10.1182/bloodadvances.2024015306. Epub ahead of print. PMID: 40408310.

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Thrombophilia

Thrombophilia

APL Positivity Cutoffs: 99th Percentile?

World Thrombosis Day Campaign: Note From Samantha Nelson, WTD Manager

World Thrombosis Day 2025

Thrombotic Thrombocytopenic Purpura

August 2025 QQ: Anticoagulant Choice for AFIB

Postpartum DIC

What is Monoclonal Gammopathy of Thrombotic Significance?

DIC Update

Invent-VTE

Inaccuracies of Venous Thromboembolism Risk Assessment

George Fritsma MS MLS

Cheat Sheets from George

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