Thrombophilia

Familial APS?

On June 1 a Fritsma Factor participant asked if there were any evidence of a familial prevalence for symptomatic antiphospholipid syndrome [APS] or lab evidence for the familial distribution of one of the antiphospholipid antibodies [APAs]: lupus anticoagulant [LA], anti-cardiolipin antibody [ACA], or anti-beta-2-glycoprotein 1. I [Geo] located only a single case report: Bhattacharya S, […]

Lupus Anticoagulant

PERT Consortium

Thanks to Paul Riley, Ph.D., Diagnostica Stago, for his introduction to the Pulmonary Embolism Response Team [PERT] Consortium. For our list of hemostasis-related links, click here. If your association does not appear in the list, please provide the website and link to me [Geo] at [email protected].

Antiphospholipid Antibodies in Gulf War Syndrome

Thanks to hemostasis researcher Dave McGlasson for sending this article that indicates lupus anticoagulant as an autoimmunity mechanism associated with Gulf War Syndrome. James LM, Johnson RA, Lewis SM, et al. Lupus anticoagulant in Gulf War Illness and autoimmune disorders: a common pathway toward autoimmunity. J Immunological Sci. 2021; 5: 14–18. Dave had published a […]

Thrombotic Microangiopathies Presentation Handout

Click for the handout for “von Willebrand Factor, Friend or Foe,” which George presented on Friday, April 21, and Friday, April 29, 2023.

Arterial Thrombosis

Age-adjusted D-dimer Cutoff

From Amberly Nunez: Hi George, I am curious to see if anyone is using the age-adjusted D-dimer cutoff for PE? I know this topic was discussed in 2014 and wanted to see if there has been a practice change since that time. We are using the STA Liatest D-Di and our ED physicians have asked […]

Webinar: The Many Faces of VWF Part 1: Von Willebrand Factor and Acquired von Willebrand Syndrome

Fritsma Factor participants, we invite you to view Part 1 of our video: series ‘Coag Conversations’ The Many Faces of von Willebrand Factor; or Von Willebrand Factor, ADAMTS13, Malignancy, and Beyond: Von Willebrand Factor and Acquired von Willebrand syndrome, A Kaleidoscope of Presentations.” This is the first of a three-part series sponsored by BioMedica Diagnostics of […]

Arterial Thrombosis

VWF: Friend or Foe

I [Geo] will present, “Von Willebrand Factor, Friend or Foe: MA, TTP, aHUS, STEC-HUS, MAHA, PLEX, TIC, ADAMTS13, VWF What Does it All Mean?” for the combined ASCLS-Alaska, -Washington, and -Oregon on Friday, April 21, 1–2 CDT, and again for ASCLS-North Dakota on Friday, April 28, 2–3 CDT. These presentations are virtual. Click here for […]

Spinal Cord Stroke

On February 26, 2023, a Fritsma Factor participant asked about a relative’s diagnosis of spinal cord stroke. Spinal cord stroke is rare, 0.3–1% of all strokes. I’ve attached a review article, Romi F, Naess H. Spinal cord infarction in clinical neurology: a review of characteristics and long-term prognosis in comparison to cerebral infarction. Eur Neurol. […]

Arterial Thrombosis

December 2022 Quick Question: Thrombosis Risk Factor Profile Response

Welcome to 2023. Our December 2022 Quick Question, which drew 45 responses, asks, “What parameter is NOT part of your thrombosis risk factor profile? The answers were: Antithrombin [1, 3%] Protein C [3, 7% ] Protein S [1, 2%] Prothrombin 20210 mutation [1, 3%] Lipoprotein [a] [38, 85%] As anticipated, most of us have dropped, […]

Quick Question Archive

December, 2022 Quick Question: Thrombosis Risk Profiles

I’ve been reviewing Choosing Wisely recommendations and Medscape discussions on the importance of assays for congenital thrombosis risk factors such as antithrombin, protein S, and protein C. We’d like to know what comprises our profiles by asking “What parameter is NOT part of your thrombosis risk factor profile?” Please access our December Quick Question on […]

Quick Question Archive

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

Quick Question