Thrombophilia

December 2022 Quick Question: Thrombosis Risk Factor Profile Response

Welcome to 2023. Our December 2022 Quick Question, which drew 45 responses, asks, “What parameter is NOT part of your thrombosis risk factor profile? The answers were: Antithrombin [1, 3%] Protein C [3, 7% ] Protein S [1, 2%] Prothrombin 20210 mutation [1, 3%] Lipoprotein [a] [38, 85%] As anticipated, most of us have dropped, […]

Quick Question Archive

December, 2022 Quick Question: Thrombosis Risk Profiles

I’ve been reviewing Choosing Wisely recommendations and Medscape discussions on the importance of assays for congenital thrombosis risk factors such as antithrombin, protein S, and protein C. We’d like to know what comprises our profiles by asking “What parameter is NOT part of your thrombosis risk factor profile?” Please access our December Quick Question on […]

Quick Question Archive

World Thrombosis Day 10-13-2022

Venous thromboembolism is a condition in which a clot forms in the deep veins of the leg, groin, or arm [deep vein thrombosis, DVT ].

Dr. Brandon Henry: Coag Conversations: All Three

George Fritsma and guest speaker Brandon Michael Henry, MD, Investigative Pathologist at the Cincinnati Children’s Hospital

August 2022 Quick Question: LAC Testing Responses

Our August 2022 Quick Question attracted 34 responses [despite our discouraging “Recaptcha” security function] and asked, “You test for lupus anticoagulant [LAC] using a low-PL PTT reagent and a hex-phase high-PL mix. The mix results are 10 seconds shorter than the first test. What do you conclude?” LAC positive 32% [11] LAC negative 18% [6] […]

Lupus Anticoagulant

August 2022 Quick Question: LAC Testing

Our August 2022 Quick Question addresses lupus anticoagulant testing, a member of the standard thrombophilia screening profile. “You test for lupus anticoagulant [LAC] using a low-PL PTT reagent and a hex-phase high-PL mix. The mix results are 10 seconds shorter than the first test. What do you conclude?” The question illustrates the PTT-based LAC test […]

Lupus Anticoagulant

Viscoelastometry for Thrombophilia

Please comment here if you are using viscoelastometry–Sonoclot, TEG 5000, TEG 6S, ROTEM, or Quantra–to detect a prothrombotic state, and please provide the parameters you employ. For detailed information, click Reda S, Morimont L, Douxfils J, Rühl H. Can we measure the individual prothrombotic or prohemorrhagic tendency by global coagulation tests? Hämostaseologie 2020;40:364–78.

EC Markers in COVID19 Thromboinflammation

The devastating COVID19 pandemic has led medical researchers led by Brandon M. Henry, MD, Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA to identify and characterize the pathophysiology of a number of thromboinflammation-related endothelial secretions. Some important terms relatively new to medical laboratory science include ADAMTS13/VWFag ratio, NETosis, and cell-free […]

Arterial Thrombosis

May 2022 QQ: Thrombosis Risk Profile Summary

We had near-100% agreement on our May 2022 Quick Question, which attracted 45 voters: “What assay should be deleted from the thrombosis risk factor profile?” Here are our selections: Protein C 0% Protein S 2% [1] Antithrombin 2% [1] Activated protein C resistance 7% [3] Prothrombin G20210A mutation 4% [2] Methylenetetrahydrofolate reductase resistance [MTHFR] polymorphism […]

Quick Question Archive

May 2022 QQ: Thrombosis Risk Profile

Our May 2022 Quick Question asks, “What assay should be deleted from the thrombosis risk factor profile?” Thrombosis risk testing has been available to us since von Kaulla first described “antithrombin 3” deficiency in 1972 using the “serum antithrombin” test. It gained momentum when Dahlbach described activated protein C resistance in 1994, and thrombosis risk […]

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

Cheat Sheets from George

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