Fibrinolysis

D-dimer: Double-spin?

Hi George. Why is it not important to double-spin D-dimer specimens for platelet poor plasma (PPP) when there’s a delay in testing? Is this because D-dimers are not affected by labile factors as other coag testing? Looking forward to your answer. Teresa Lovejoy, MT (ASCP) Senior Medical Technologist, Hematology Children’s of Alabama. Birmingham, AL Hi, […]

Lipemia, Hemolysis, and D-dimer

From “Cristina:” What is the reason why lipemic and hemolyzed coagulation sample should be rejected? Is it only the D-dimer is susceptible? Thanks. Hello, and thank you for your question. Lipemia is likely to cloud the final reaction solution in a photo-optical method, interfering with the results. On all instruments, the quantitative D-dimer is a […]

More on D-dimer in FVL

I’ve received four expert follow-up comments to our July 5 D-dimer Efficacy in Factor V Leiden Mutation post. Here they are, in order of receipt: From Dr Emmanuel J Favaloro, Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, NSW Australia: Hi George, I have no idea about FVL influencing D-dimer development; I would […]

D-dimer Efficacy in Factor V Leiden Mutation

This 6/30/2012 question from a physician arrived through the American Society for Clinical Laboratory Science Consumer Web Forum. “Does delayed fibrinolysis in a known factor V Leiden (FVL) mutation patient reduce the value of a negative D-dimer test?” George’s initial response: Thank you for your question. I was prepared to answer that there is no connection, […]

Who Does D-dimer on Destiny Max?

Crystal Azavedo at EMH asks: Hi, George. I am looking for users of the Destiny Maxwho are using the analyzer to run quantitative D-dimer. I’m seriously considering adding the analyzer to our platform, but I haven’t heard from any local (northeast US) users that have put DD onboard. Thanks for all your help! Hi, Crystal, I invite […]

DIC: Marker Recovery Time in Therapy

From “Siddhartha,” In disseminated intravascular coagulopathy (DIC) patients, what is the minimum time for the coagulation parameters D-dimer, fibrin degradation products (FDP) and fibrinogen to return to normal levels post frozen plasma (FFP) transfusion? Is it really worthwhile to do these tests in a suspected case of DIC who has already received FFP? Thanks, Siddhartha. […]

High D-dimer, low Fibrin Monomer in Amyloidosis

From “rhe25“: Hi, George, glad to find your resourceful website! Question for you: when the D-dimer is very very high, but the soluble fibrin monomer complex (SFMC) is negative, does that mean primary fibrinolysis in a systemic amyloidosis patient who has bleeding? I have seen a case like this, but the fibrinogen level is elevated, […]

VMAX Error Implies Low Fibrinogen

From Julia Witt, SH (ASCP), Hematology Supervisor, Smith-Glynn-Callaway Clinic, Springfield, MO: Monday, December 26: We recently had a patient present with an MI. He is on a standard treatment regiment. Upon his arrival at the hospital, baseline coagulation studies were performed. The fibrinogen result exceeds the linearity of the analyzer. A 1:1 dilution utilizing pooled normal […]

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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