August 2025 CAP Today: D-dimer Reporting and INR Are Variables That Matter

In follow-up to their July 2025 CAP Today article, A Deep Dive into Key Hemostasis Testing Variables, Drs. Andrew Goodwin and Eric Salazar present external quality improvement data on the PT–INR, D-dimer, and VET in their August 2025 article, D-dimer Reporting and INR Are Variables That Matter. Their article in particular examines the confusion over […]

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Anticoagulant Therapy

Dec 15 2025

george

Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

A summary by Dr. Wolfgang Miesbach: A potential landmark thrombolytic innovation presented at ASH 2025. Thrilled by the exciting Phase 1 data presentation by Marie Scully and co-authors on TGD001, a groundbreaking novel von Willebrand factor (VWF)-targeting thrombolytic: First-of-its-kind mechanism: TGD001 is an antibody-enzyme fusion protein—specifically, an anti-VWF antibody fragment fused to a urokinase catalytic domain. […]

Arterial Thrombosis

Red Light Therapy in Hemostasis and Thrombosis

Check with your medical library for an advanced study of the effects of red light therapy upon hemostasis: Fan BE, Pasalic L, Hew YY, Lippi G, Favaloro EJ. Red light therapy in thrombosis and hemostasis. Semin Thromb Hemost. 2025. doi: 10.1055/a-2717-5157. Epub ahead of print. PMID: 41062078. Abstract Red light therapy is emerging as a […]

Antiplatelet Therapy

Two Cases of Brown Recluse Envenomation

Here is an open-access article that describes cases that illustrate the coagulopathy associated with brown recluse spider bites. Hart SA, Gailani D, Bibb LA, et al. Coagulation abnormalities following brown recluse spider (Loxosceles reclusa) envenomation: A description of 2 cases and review of the literature. Am J Clin Pathol. 2025;163:822–36. doi: 10.1093/ajcp/aqaf001. PMID: 39883062; PMCID: […]

Thrombophilia

Postpartum DIC

Check with your medical library for this review, dated 7-18-25. Wolfovitz A, Brenner B, Solt I. Postpartum disseminated intravascular coagulation: A comprehensive review of pathophysiology, diagnosis, management, and prevention. Semin Thromb Hemost. doi: 10.1055/a-2645-2845. Epub ahead of print. PMID: 40680793. Abstract Disseminated intravascular coagulation (DIC) in the postpartum period is a rare but potentially life-threatening […]

Fibrinolysis

June 2025 Quick Question Summary: Fibrinolysis

Our June 2025 Quick Question was a quiz that asked, “Which fibrinolysis component directly digests fibrin?” Our 51 respondents answered… Plasminogen: 12 (23%) Antiplasmin: 0 D-dimer: 1 (2%) Plasmin: 37 (73%) TPA: 1 (2%) The correct answer is #4, plasmin. In brief, plasminogen is a zymogen. Plasmin, the activated form of plasminogen, binds and digests […]

Fibrinolysis

Neutrophil Extracellular Traps

Neutrophil extracellular trap (NET) research has gained prominence beginning in perhaps 2010. I’ve attached an open-access review that illustrates NETs‘ functions and shows how NETs connect neutrophils with hemostasis. The article also documents how NETs participate in the process of thrombosis. Click to download Huang G, Wu H, Lin B, et al. Targeting neutrophil extracellular […]

Blog

Updated DIC Parameters from ISTH

The ISTH SSC Subcommittee on Disseminated Intravascular Coagulation has published its latest definition and scoring system for DIC. You may obtain the article from your medical library or through your ISTH membership. Iba T, Levy JH, Maier CL, et al. Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC […]

Bleeding Disorders

June 2025 Quick Question: Fibrinolysis

Our June 2025 Quick Question asks, Which fibrinolysis component directly digests fibrin? Please find the question on the right side of the “Posts” menu and make your selection. As always, we invite your comments using the function below.

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Quick Question Archive

Mar 7 2024

george

Still More on Chronically Elevated D-dimer

We’ve received an additional comment on our February 3, 2024 entry on the topic of chronically elevated D-dimer.

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Fibrinolysis

Fibrinolysis

August 2025 CAP Today: D-dimer Reporting and INR Are Variables That Matter

Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

Red Light Therapy in Hemostasis and Thrombosis

Two Cases of Brown Recluse Envenomation

Postpartum DIC

June 2025 Quick Question Summary: Fibrinolysis

Neutrophil Extracellular Traps

Updated DIC Parameters from ISTH

June 2025 Quick Question: Fibrinolysis

Still More on Chronically Elevated D-dimer

George Fritsma MS MLS

Cheat Sheets from George

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