Coagulation Factors

Modified Nijmegen Bethesda Assay

On March 13, 2018. Precision BioLogic Inc., Dartmouth, NS, announced their development of a new approach to standardize and improve factor VIII inhibitor testing. Their press release (tap or click) referenced new data presented in a poster at the Thrombosis and Hemostasis Societies of North America, March 8–10, 2018 meeting, in San Diego, CA, USA. […]

Bleeding Disorders

Yet More on Reference Intervals

This is a follow-up comment from Bob Gosselin on Griselle Font-Bonet’s December 31 post about reference intervals. The original post drew many thoughtful and provocative comments from Dave McGlasson, and Drs. Ali Sadeghi-Khomami and Emmanuel Favaloro; consequently, it became so long that an add-on comment would make it unwieldly. Bob says these “last thoughts”… Lest […]

Bleeding Disorders

Undergrad Hemostasis Education

This June 29, 2016 note was posted by Patricia Boyer, MS, MLS, Program Director, Zablocki VAMC School of Medical Technology to the American Society for Clinical Laboratory Science educators bulletin board: I am working on my hemostasis curriculum, and I was wondering how many instructors teach coagulation using the multicomponent complexes–specifically the tenase and prothrombinase complexes concepts. This is my second year […]

Arterial Thrombosis

New Quick Question: Bethesda Titers

Please review and vote on our May, 2016 Quick Question, “How does your laboratory measure factor inhibitors?” in preparation for our Thursday, June 2 Webinar described below. George will report on your Quick Question findings. If none of the answers reflect your policy, please add a comment to this entry. Please join Precision BioLogic Inc, […]

Bleeding Disorders

More on Elevated PC Activity

We’ve had four substantive comments on Kelly Townsend’s January 12, 2016 post about elevated protein C activity, including recent communications from two frequent contributors, Donna Castellone and Dr. Vadim Koustosov. Your comments are also welcome. Geo.

Coagulation Factors

Factor XII Deficiency and the Intrinsic Pathway

Ellie Coggins, MLS(ASCP)CM, MSHA, writes, I have a coagulation question I’m hoping you can help me with. I am wondering why factor VII deficiency causes significant bleeding problems but factor XII deficiency does not. One source I found stated that this is because the extrinsic pathway is the primary pathway in vivo and that the […]

Coagulation Factors

Pediatric Reference Intervals

From Dr. Jasmina Ahluwalia: Dear George, I wonder if you could help me. Is there is a recent reference range available for the pediatric population for the coagulation screening tests, factor assays, protein C, protein S and antithrombin assays on the ACL TOP systems? I did come across one on the STAGO and Sysmex systems […]

Coagulation Factors

TIC Presentation

Thanks to everyone who attended my presentation, “Trauma-Induced Coagulopathy” on Friday, June 19 on the Auburn University at Montgomery campus, and thanks to Kathy Jones and the organizers for the invitation. As promised, the handout for my presentation is now available on my previous post.

Bleeding Disorders

Don’t Worry–Be Happy

Donna Castellone of New York Presbyterian posted an interesting discussion of emotional stress and inflammatory markers in her column, “Don’t Worry, Be Happy,” linked here.

Arterial Thrombosis

Unexplained Prolonged PTT

From Dr. Samir Patel: George, I have enjoyed reading the blog for many years now (since fellowship) and am wondering if you could shed some light on a patient I am working up. This is a 90 year old woman who was sent for evaluation after she developed a hematoma post cardiac catheterization (no need […]

Coagulation Factors

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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