Bleeding Disorders

Rare Bleeding Disorders

I thank Marisa Marques, MD, Professor, Pathology Department, University of Alabama at Birmingham, for introducing me to a concise review article, Palla R, Peyvandi F, Shapiro AD. Rare bleeding disorders” diagnosis and treatment. Blood 2015;125:2052–61, available free from The American Society of Hematology. The article answers many questions about the rare deficiencies of factors II, […]

Bleeding Disorders

World Hemophilia Day April 17

From the World Federation of Hemophilia (Thanks to Elaine Benoit, Precision BioLogic Inc for the heads-up): Building a Family of Support on April 17, World Hemophilia Day Every year on April 17, World Hemophilia Day is observed around the world to increase awareness of hemophilia and other inherited bleeding disorders. This is a critical effort […]

Bleeding Disorders

PT Affected by LMWH?

Sam Arcidiacono asks, One of our customers had a patient who stopped Coumadin for surgery and was given Lovenox (LMWH) I believe after the surgery. PT was 20 seconds on admission, day after surgery PT was 205 seconds then 275 that evening. I didn’t think it was due to the Lovenox. No Lovenox was given […]

Bleeding Disorders

Bethesda Titer

Cassandra McGeachy, Louisiana Coagulation, asks, I am trying to evaluate a set of FVIII inhibitor results and I am not sure what to call it. My patient + normal pool on my Bethesda assay yields a 23% FVIII and the next 4 serial dilutions bounce around between 15 to 19% instead of giving a higher […]

Bleeding Disorders

Coagulation Studies for the Ebola Patient

Pat Doleski suggests that the recommended Ebola patient coagulation test is the PT. What is the hemorrhagic process that occurs in the Ebola patient that the PT is the best screening to direct the use of blood products? We are in the process of setting up a secure ER lab specifically for this type of […]

Bleeding Disorders

Vetigel

The January 1, 2015 issue of Fortune contains a brief article about Vetigel, which the writer describes as a “liquid bandage.” Vetigel, under development by Suneris, is initially targeted to the veterinary market, but will become available to the military, first responders, and eventually the public pending FDA clearance. Vetigel is a vegetable product that, […]

Bleeding Disorders

Transfusion News

Thanks to John Gerlach, PhD, Michigan State University for introducing us to Transfusion News, supported by Ortho Clinical Diagnostics. I’ve added Transfusion News to our Links page.

Bleeding Disorders

Yet More on Promacta

This is from friend and colleague, Dean Willett, Instrumentation Laboratory: Hi, George; A few points to consider… There are two potential sources of interference here: biochemical and optical. Much like hemolysis, if the sample contains biochemical interference, results will be affected regardless of detection method. In the absence of any data it’s not clear if this drug […]

Bleeding Disorders

More on Promacta

From my friend Ali Sadeghi-Khomami, PhD, Precision Biologic Inc: Eltrombopag is a diazo derived compound that acts like pH indicators, i. e., it changes colour at different concentrations of hydronium ions. Thus it is expected that it interferes with chromogenic assays such as the bilirubin assay, especially when assay calibration will not match the colour of the testing sample. […]

Bleeding Disorders

Promacta and Brown Plasma

From John Mitsios, MD at Cornell. Hi George! I had a question regarding the effects of eltrombopag (Promacta®, a TPO stimulating agent), which is typically given to patients with immune thrombocytopenic purpura (ITP), on routine coagulation assays. The reason for this question is that it has been observed in some patients that at high doses the plasma […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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