Bleeding Disorders

PBI FVIII Inhibitor Kit Approved

On March 13, 2019, Precision BioLogic Inc. announced US FDA clearance for the new CRYOcheck Factor VIII Inhibitor Kit. Click or tap here for the complete news release. This clearance follows approvals received from regulatory authorities in Canada, the European Union, Australia, and New Zealand, where the kit launched in February of this year. The […]

Bleeding Disorders

Quick Question: 41 YO Man With GI Bleeding Response

Our February, 2019 Quick Question was a case study entitled, “41-YO Man with GI Bleeding” (click or tap to review). For 56 responders, the answers and tallies were… Vitamin K deficiency 9% (5) Moderate liver disease 57% (32) Functional platelet disorder 4% (2) Disseminated intravascular coagulation 21% (12) Other: please provide a written response 9% […]

Bleeding Disorders

New FVIII Inhibitor Assay

An exciting news release from Precision BioLogic Inc. Today, we are announcing the availability of our new CRYOcheck Factor VIII Inhibitor Kit in Canada, the European Union, Australia, and New Zealand following market authorization by Health Canada and respective in-country regulatory authorities in January. Click here for full information about the CRYOcheck Factor VIII Inhibitor […]

Bleeding Disorders

Quick Question: 41 YO Man With GI Bleeding

February 1, 2019 Quick Question Case A 41-year-old man was admitted with severe gastrointestinal bleeding. He reported that he drinks an average of 15 ounces of whiskey per day, a habit of 15 years. Upon admission he was given Librium for withdrawal and parenteral nutrition with multivitamins. He was jaundiced and reported the jaundice had […]

Bleeding Disorders

Quick Question: 6 YO Boy with Chronic Bleeding

Please click or tap our December 31, 2018 Quick Question post, a case study of a 6-year-old boy with chronic bleeding. We had a 2018–19 record 76 responses. The choices and responses are as follows. Answers Platelet function abnormality: 10 (13%) Von Willebrand disease: 14 (18%) Factor VII deficiency: 4 (5%) Factor XII deficiency: 4 […]

Bleeding Disorders

Assaying Factor Concentrates

A pre-publication article, Young G, Perry D, The International Prophylaxis Study Group (IPSG). Laboratory assay measurement of modified clotting factor concentrates: a review of the literature and recommendations for practice. J Thromb Haemostas pre-publication, 1-22-19 provides advice on how to measure extended half-life and B-domain-deleted factor concentrates VIII and IX. The article illustrates the wide […]

Bleeding Disorders

Nijmegen-Bethesda Assay

Beginning with a 2016 Quick Question and continuing to our most recent post in March, 2018, we’ve devoted altogether six entries to the 2012 CDC refinements of the Nijmegen-Bethesda assay. These have culminated in the following material, which appears in Fritsma GA, Chapter 41, Laboratory Evaluation of Hemostasis; in Keohane EM, Otto C, Walenga JM. […]

Bleeding Disorders

Platelet Signaling Disorder

A patient experiences chronic moderate bleeding from a surgical site and venipuncture sites over 48 months. The bleeds consistently require intervention. There is no epistaxis and minor bruising. The only diagnostic laboratory result is impaired aggregation epinephrine and ADP agonists, and absence of arachidonic acid-induced aggregation. All other hemostasis and hematology results report within their […]

Bleeding Disorders

Case: 6-year-old Boy with Chronic Bleeding

(Thanks to Dave McGlasson for this case study) A six-year-old boy presented with a history of joint bleeds, hematomas, and occasional deep muscular bleeds. His parents reported that he had experienced no umbilical bleeding but bled from circumcision at two days of age, reaching a hemoglobin level of 3.1 g/dL, requiring transfusions and surgery. There […]

Bleeding Disorders

Case: 37 year-old Female with Lifelong Epistaxis

(Case provided by Dave McGlasson, please click on Comments to answer) A 37 year-old female complains of recurrent severe epistaxis (nosebleeds) since childhood, occasionally requiring packing or cauterization. She also reports menorrhagia since menarche (menstruation onset) and easy bruising. She experienced no abnormal bleeding during three successful pregnancies. Her father also experiences epistaxis, easy bruising, […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

Cheat Sheets from George

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