Bleeding Disorders

FVII Deficiency

I [Geo] received this post on Monday, December 18: Hi George, I have a few questions that I was hoping you could help me with. I’m a patient with factor 7 deficiency and have a background in nursing. I was diagnosed at 49% but have had issues with fluctuations in percentages between standalone labs and […]

Bleeding Disorders

Acquired Hemophilia, rpVIII, and Bethesda Titer

Here is a 12-2-23 email from Hrvoje Melinšćak MD, Consultant in Haematology, the Warren Alpert Medical School of Brown University, Rhode Island Hospital/The Miriam Hospital. I would enquire regarding rpFVIII’s impact on inhibitor titre assessment through the Bethesda assay in a case regarding acquired haemophilia A. Does significant background rpFVIII (Obizur) concentrate lend to significant […]

Bleeding Disorders

Trauma-induced Coagulopathy Conversation Part 3

Part 3 of my Coag Conversation with Dr. Maureane Hoffman entitled Trauma-induced Coagulopathy; The Laboratory’s Role in Care, is now available from the BioMedica Diagnostics website.

Bleeding Disorders

December 2023 Quick Question: VWD Subtype 2B

Our December 2023 Quick Question asks, “How do you test for VWD subtype 2B?” This is in follow-up to our February 2023 question, “What VWF activity assay do you use?” VWD subtype 2B is a qualitative VWF deficiency caused by a gain-of-function mutation that increases VWF-platelet-binding avidity. Please answer the quiz and post your comments […]

Bleeding Disorders

Recombinant ADAMTS13 Therapeutic

On November 9, 2023, Takeda’s recombinant ADAMTS13 received FDA approval for the care of congenital thrombotic thrombocytopenic purpura [cTTP]. Click here for their news release. Click here for the US Thrombotic Microangiopathy Alliance for more cTTP information and information on the family of TMAs.

Bleeding Disorders

ISTH Releases Management of Chemotherapy-induced Thrombocytopenia

The ISTH Subcommittee on Hemostasis & Malignancy just released the following guidelines. Soff G, Leader A, Al-Samkari H, et al.. Management of chemotherapy induced thrombocytopenia: Guidance from the ISTH Subcommittee on Hemostasis & Malignancy. J Thromb Haemost. 2023;10:S1538-7836(23)00734-1. doi: 10.1016/j.jtha.2023.09.031. Epub ahead of print. PMID: 37827380.

Platelet Function Testing

Northeast Laboratory Conference, 10/17–18, 2023

the Northeast Laboratory Conference is this week, Tuesday, October 17, and Wednesday, October 18 at the Holiday Inn By the Bay, 88 Spring Street, Portland Main. I [Geo] lead an interactive session, “Trauma-Induced Coagulopathy and Massive Transfusion Protocol,” geared toward Hematology, Hemostasis, and Transfusion Medicine specialists from 10–11:30. Click here for the handout. My second […]

Bleeding Disorders

Von Willebrand Disease Subtype 2N

Von Willebrand disease subtype 2N is an autosomal recessive disorder in which the VWF D’D3-domain FVIII binding site is defective. Nearly 100% of FVIII circulates in a dynamic complex with normal VWF protected from activated protein C lysis. FVIIi, like carrier molecule VWF, has a 12-hour half-life. Uncomplexed FVIII in VWD subtype 2N has a […]

Bleeding Disorders

FVIII-depleted Plasma with VWF

Precision BioLogic’s successful Factor VIII Deficient Plasma with VWF is now FDA-cleared for sale in the U.S. [Precision BioLogic supports Fritsma Factor]

Bleeding Disorders

Erroneous Factor Assay Order?

Here is a 9-21-23 follow-up from Dr. Emmanuel Favaloro to our provocative September 8, 2023 discussion, Arabic Numerals. “OK, here’s one from today! Specimen management staff booked the sample for factors XIII, IX, XI, and XII! FVIII was not booked in.” Bob Gosselin responded, “Whatever is chosen, there will be those industrious few who will […]

Bleeding Disorders

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George Fritsma is a medical laboratory scientist, educator, and author. George is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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