Arterial Thrombosis

More on Covid and LAC

Thanks to Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc., for sending a current editorial in press, Aubignat M, Godefroy O. COVID-19 and ischemic stroke: Should we systematically look for lupus anticoagulant and antiphospholipid antibodies? Revue neurologique 2020, https://doi.org/10.1016/j.neurol.2020.05.001. Please refer to our May 6 entry on antiphospholipid syndrome and the comment from Dr. Ning Tang. The […]

Anticoagulant Therapy

Quick Question: TTP Laboratory Assay

Our June, 2019 Quick Question generated a near-unanimous response from 68 voters: What laboratory assay confirms thrombotic thrombocytopenic purpura (TTP)? Shiga toxin test: 3% (2) Complement C3 level: 7% (5) ADAMTS13 activity: 83% (56) VWF multimers: 7% (5) The Shiga toxin test correlates to Shiga toxin-induced hemolytic-uremic syndrome (ST-HUS), the “classic” HUS detected mainly in […]

Arterial Thrombosis

Wearable Clot Detector

Nephrologist Vinay Narasimha Krishna, M.D, University of Alabama at Birmingham, developed a wearable clot detection device for which he received one of 15 KidneyX Redesign Dialysis prizes from the U.S. Department of Health and Human Services and the American Society of Nephrology. The device is designed to be worn over the dialysis fistula in real […]

Arterial Thrombosis

Hyperglycemia and Stroke Outcome

The iSPOT study links treatment outcomes for acute isechemic stroke in hyperglycemic patients with markers of tissue factor pathway activation, as reported on March 5, 2019 in The Heart.org. Click or tap here for details.

Arterial Thrombosis

REDUCE-IT Trial Results

Today, Saturday, November 10, 2018, Dr. Deepak Bhatt, principal investigator of the Evaluation of the Effect of AMR101 on Cardiovascular Health and Mortality in Hypertriglyceridemic Patients With Cardiovascular Disease or at High Risk for Cardiovascular Disease: REDUCE-IT (Reduction of Cardiovascular Events With EPA – Intervention Trial) reported on encouraging results of the use of high-dose […]

Antiplatelet Therapy

VITAL Trial Results

Click or tap here to learn the results of the VITAL trial conducted by Joann Manson, MD DPH, Beth Israel. The trial looked at the primary endpoints of major cardiovascular disease events and invasive cancer in subjects taking marine omega-3 fatty acids (Omacor® fish oil, (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]], 1 g daily, […]

Antiplatelet Therapy

Aspirin Efficacy

Here is a reference to a brilliant review of current aspirin efficacy studies, focusing especially on the prospective random control trial ASPREE published in the September, 2018 New England Journal of Medicine. Lippi G, Danese E, Favaloro EL. Harms and Benefits of Using Aspirin for Primary Prevention of Cardiovascular Disease: A Narrative Overview. Semin Hemostas […]

Arterial Thrombosis

C-reactive Protein

From Ali Sadeghi-Khomami, Precision BioLogic: Hi George, First of all congratulations for a decade of your valuable blog. It came certainly a long way and proudly as well. Your blog nowadays is the first site visited by many researchers who are seeking to find a solution for their coag problem. I hope to see its […]

Arterial Thrombosis

Hematocrit and Thrombosis

Thanks to John Gerlach, PhD, Professor and Director of the Biomedical Laboratory Diagnostics Program at Michigan State University for the heads-up on this Transfusion Journal article about high hematocrit and thrombosis, which cites two 2017 Blood publications describing several arterial experiments in mice that could have clinical implications.

Arterial Thrombosis

Undergrad Hemostasis Education

This June 29, 2016 note was posted by Patricia Boyer, MS, MLS, Program Director, Zablocki VAMC School of Medical Technology to the American Society for Clinical Laboratory Science educators bulletin board: I am working on my hemostasis curriculum, and I was wondering how many instructors teach coagulation using the multicomponent complexes–specifically the tenase and prothrombinase complexes concepts. This is my second year […]

Arterial Thrombosis

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George Fritsma is a medical laboratory scientist, educator, and author. George holds faculty appointments with Rutgers University and Michigan State University, and is a member of the International Society on Thrombosis and Hemostasis, American Association of Clinical Chemists, and American Society for Clinical Laboratory Science.

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