Jul 6 2026

george

External Quality Assessment for Anti-FXa LMWH Assays

Check with your local medical library for this thought-provoking article: Favaloro EJ, Arunachalam S, Pasalic L. External quality assessment for low molecular weight heparin monitoring in the Australasia/Asia-Pacific region. Semin Thromb Hemost. 2026. doi: 10.1055/a-2900-7026. Epub ahead of print. PMID: 42398957. Abstract LMWH remains a widely used parenteral anticoagulant in hospital and outpatient settings for […]

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Anticoagulant Therapy

Jul 6 2026

george

What is Anticoagulation Drift?

Click to read this LinkedIn post, where Edward Lee Carter, BSPharm, CPP, states: “The greatest threat to long-term anticoagulation may not be choosing the wrong drug. It may be failing to recognize that the patient has changed.” He illustrates the value of clinical laboratory assays to periodically confirm DOAC dosages.

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Anticoagulant Therapy

Jul 4 2026

george

Are we Overusing LMWH?

A provocative open-access article posted on LinkedIn by Dr. Emmanuel Favaloro suggesting we are overusing LMWH: Gurumurthy G, Fan B, Gurumurthy J, et al. Should we focus on sustainable thromboprophylaxis and avoid overuse of low-molecular-weight heparins? Research and Practice in Thrombosis and Haemostasis, 2026; 10. DOI: 10.1016/j.rpth.2026.106794. Abstract Low-molecular-weight heparins (LMWHs) have become a near-routine prescription […]

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Anticoagulant Therapy

Jul 2 2026

george

DOAC Monitoring–What to Order

Ifeanyichukwu Ifechidere, Specialist Biomedical Scientist at Sheffield Teaching Hospital NHS Foundation Trust, shared her column, DOAC Monitoring–What to Order, When, and Why in Hemostasis Today.

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Anticoagulant Therapy

May 15 2026

george

Perioperative Management of Antiphospholipid Syndrome Study

Click here for the open-access article, Paquette M, Miranda S, Xu Y, et al. Perioperative management of antithrombotic therapy in patients with thrombotic antiphospholipid syndrome. Blood Adv. 2026;10(9):3218–28. doi: 10.1182/bloodadvances.2026019610. PMID: 41843780; PMCID: PMC13136740. Abstract Patients with thrombotic antiphospholipid syndrome (APS) frequently require interruption of anticoagulation for invasive procedures; however, data to guide the perioperative […]

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Anticoagulant Therapy

Mar 28 2026

george

April 2026 QQ: VWF Activity

Our April 2026 QQ, “How do you measure VWF activity,” reprises our February 2023 QQ that asked: “What VWF Activity Assay do you use?” Discussions at the March 2026 THSNA meeting in Portland, Oregon, USA, have prompted me (Geo) to learn if our choices have changed in three years. We await new data for the […]

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Anticoagulant Therapy

Mar 28 2026

george

March 2026 QQ: LAC Assay

Our March 2026 Quick Question was a poll that asked: “How do you test for LAC when the patient is on a DOAC?” Our 19 respondents answered: Don’t test: 3 (15%) Go ahead and test: 2 (11%) Use a DOAC neutralizer: 12 (63%) Test only for anticardiolipin antibody and anti-Β2GP1: 2 (11%) The DOAC neutralizers […]

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Anticoagulant Therapy

Mar 24 2026

george

Global Anticoagulant Supply

Here is an open-access editorial describing a critical worldwide shortage of safe therapeutic anticoagulants. Fan BE, Yee Tang JK, Favaloro EJ. Safeguarding global anticoagulant supply and access. J Thromb Haemost. 2026:S1538-7836(26)00134-0. doi: 10.1016/j.jtha.2026.02.017. PMID: 41791674. Abstract Anticoagulants are essential to healthcare, yet their global supply is inherently fragile. Reliance on animal-derived heparin creates vulnerability to […]

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Anticoagulant Therapy

Mar 15 2026

george

Review and History: Protamine and Gene Therapy

Here is a provocative article available from your medical library: Thachil J. Protamine–the journey from DNA to heparin neutralization to gene therapy. Semin Thromb Hemost. 2022;48:240-243. doi: 10.1055/s-0041-1736574. PMID: 34729729. Abstract Protamine is now well recognized as a key heparin-neutralizing agent. However, protamine was discovered over a century ago, during experiments performed to uncover the […]

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Anticoagulant Therapy

Mar 10 2026

george

Anticoagulant Monitoring in ECMO

Here’s a provocative open-access essay that reviews the efficacy of current anticoagulant monitoring in ECMO: Rajsic S, Treml B. Anticoagulation monitoring during ECMO support: monitor or flip a coin? Clin Cardiol. 2024;47(12):e70061. doi: 10.1002/clc.70061. PMID: 39692163; PMCID: PMC11653157. Abstract Should we rely on anticoagulation monitoring in ECMO patients or simply flip a coin? The increasing […]

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Anticoagulant Therapy