PTT and C-reactive Protein

From Dean Willett, Precision BioLogic Inc. As I read the 11-8-17 comments from Dr. Elman a bit of a lightbulb went off in my head. I’m sure you’ve seen the various publications that demonstrate the effect of C reactive protein (CRP) on APTT assays. Here are: https://www.ncbi.nlm.nih.gov/pubmed/22224499; and https://biblio.ugent.be/publication/5838447/file/6839536. There have been some proficiency samples […]

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Lupus Anticoagulant

Nov 8 2017

george

LAC Profile: PTT Versus PTT-LA

From “Ari.” Hi George, I stumbled upon your amazing site when researching this question and was wondering if you could shed some light on this. I have a patient who had a DVT. His PCP noted a slightly prolonged aPTT and sent mixing studies. From what I can tell, the aPTT mostly corrected with mix, […]

Lupus Anticoagulant

Clinical Diagnostics & Research 2017 November 8 & 9

Labroots offers Clinical Diagnostics & Research Wednesday and Thursday, 11/8–11/9, 2017, a virtual event featuring webinars about Diagnostic Analysis and Management, the ABIM/Consumer Reports Choosing Wisely Initiative, Mental Health and Healthy Aging, Vitamin D, Pain Management, and Evolution Biomarkers and Regulation in Clinical Labs. George Fritsma will speak at 9 AM ET on the Consumer […]

Events

When to Collect Thrombophilia Specimens

George has been communicating with Drs. Elaine Keohane (Rutgers) and Larry Smith (Abbott) about how long to wait after a thrombotic event to collect a specimen for a thrombosis risk profile. Thrombosis risk profiles include assays for antithrombin, protein C, and protein S deficiencies, which can’t be accurately measured during periods of acute inflammation (such […]

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Anticoagulant Therapy

Nov 2 2017

george

When to Label Tubes

On October 25, 2017, Heather DeVries, Indiana University Health, initiated a provocative discussion on the storage and transport of PTT specimens. Dr. Emmanuel Favaloro commented, providing some potential liberalization of the time limits imposed in the CLSI H21-A5 guideline. He also provided a reference, Lippi G, Salvagno GL, Montagnana M, Lima-Oliveira G, Guidi GC, Favaloro […]

Specimen Management

Applicator Sticks

This message came to George via Elaine Benoit, Precision BioLogic Inc. Good evening Mr George, I accidentally came across the site and I am very happy to have found you. First of all I apologize for English. I am passionate about in vitro haemostasis. In December 2013 I thought and applied a post-analytical sample clotting […]

Specimen Management

October 2017 QQ Responses

Our Quick Question for October, 2017 was a quiz question with one correct answer: you perform platelet aggregometry. Aggregation results are normal in response to all agonists except ristocetin. You rule out VWD. What diagnosis could it be? a. Bernard-Soulier syndrome: 47 (61%) b. Glanzmann thrombasthenia: 18 (24%) c. Aspirin-like syndrome: 8 (10%) d. Storage […]

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Platelet Function Testing

Oct 25 2017

george

Storing Unspun PTT Specimens

From our colleague and frequent contributor Heather DeVries, Indiana University Health. Greetings George! One of our labs contacted me about PTT specimens coming from outpatient clinics, where they do not have centrifuges. Before coming into our system, this lab did a small study (30 specimens) to validate 24-hour stability of nonheparinized specimens for PTT testing. […]

Specimen Management

TXA in DIC

A colleague asks what people are doing in regards to the antifibrinolytic TXA use in patients with DIC who are massively hemorrhaging. George has found a number of articles describing the efficacy of tranexamic acid and epsilon-amino-caproic acid in treating post-partum hemorrhage, which is close, but nothing directly recording TXA in DIC. If you have […]

Fibrinolysis

Kim Wilson wins Quick Guide Series

Congratulations to Kim Wilson, NorDx Laboratories, Portland ME, winner of the AACC Quick Guide series, awarded by Precision BioLogic, Inc, Dartmouth Nova Scotia at the 2017 Northeast Laboratory Conference, October 17–19, 2017. George Fritsma presented the 14-title Quick Guide series at the Precision booth on Wednesday, October 18. The series includes, among other texts, Marques […]

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Events

All Posts

PTT and C-reactive Protein

LAC Profile: PTT Versus PTT-LA

Clinical Diagnostics & Research 2017 November 8 & 9

When to Collect Thrombophilia Specimens

When to Label Tubes

Applicator Sticks

October 2017 QQ Responses

Storing Unspun PTT Specimens

TXA in DIC

Kim Wilson wins Quick Guide Series

George Fritsma MS MLS

Cheat Sheets from George

Questions or Comments?

Quick Question