Aspirin v. Clopidogrel in Dual Antiplatelet Therapy

Obtain this article from your medical library: Rubboli A, Pompei G, De Rosa S, et al. Clopidogrel vs. aspirin in addition to oral anticoagulation as part of double antithrombotic therapy following PCI: a post-hoc analysis of the PERSEO registry. J Thromb Thrombolysis. 2026 Apr 20. doi: 10.1007/s11239-026-03286-4. PMID: 42008084. Abstract In patients on oral anticoagulation […]

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Antiplatelet Therapy

May 26 2026

george

A 2026 Review of D-dimer Reporting Variations in VTE

Here is an open-access 2026 review that illustrates the reporting variations and application of the D-dimer assay in VTE. Hofstetter RV, Marx CE, Kraaijpoel N, Favaloro EJ, et al. Reporting of D-dimer testing in venous thromboembolism diagnostic management studies: a scoping review. J Thromb Haemost. 2026:S1538-7836(26)00190-X. doi: 10.1016/j.jtha.2026.03.005. PMID: 41839295. Abstract Background: D-dimer testing is […]

Thrombophilia

Cell-based Coagulation Model

Our Coagulation Overview Module, linked on May 15, 2026, may be more accurately called the Plasma-based Coagulation Overview Module. The plasma-based coagulation “cascade” model, described in Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry. 1991;30:10363–70. doi: 10.1021/bi00107a001. PMID: 1931959, is the basis for clot-based tests, the PT, PTT, TT, […]

Coagulation Factors

Tissue Factor Activity and Ischemia

Access this open-access article that describes a relationship between plasma TF levels, cancer-related ischemia, and elevated D-dimer: Gon Y, Kawano T, Kitano T, et al. Tissue factor activity and 1-year mortality in patients with active cancer and acute ischemic stroke: findings from the SCAN study. Res Pract Thromb Haemost. 2026;10(1):103347. doi: 10.1016/j.rpth.2026.103347. PMID: 41695667; PMCID: […]

Arterial Thrombosis

Cord Blood VWF & FVIII Levels

On Monday, 5-18-26, Stuart Lind, MD, University of Colorado Hospital and School of Medicine, asked, “Would you know of any primary references that validate cord blood levels?” A PubMed search yielded this reference describing VWF levels, available from your medical library: Schneider DM, von Tempelhoff GF, Herrle B, Heilmann L. Maternal and cord blood hemostasis […]

Coagulation Factors

Clot Waveform Analysis

Click here for this open-access article on waveform analysis and for access to Seminars in Thrombosis and Hemostasis Issue 4, 2026: Tan JY, Raden M, De Guzman T, Wong WH. Decoding clot waveform analysis: toward better understanding and harmonization. Semin Thromb Hemost 2026; 52(04): 460-475 DOI: 10.1055/a-2778-9810. Abstract Clot waveform analysis (CWA) extends routine coagulation […]

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Global Hemostasis Assays

May 15 2026

george

Perioperative Management of Antiphospholipid Syndrome Study

Click here for the open-access article, Paquette M, Miranda S, Xu Y, et al. Perioperative management of antithrombotic therapy in patients with thrombotic antiphospholipid syndrome. Blood Adv. 2026;10(9):3218–28. doi: 10.1182/bloodadvances.2026019610. PMID: 41843780; PMCID: PMC13136740. Abstract Patients with thrombotic antiphospholipid syndrome (APS) frequently require interruption of anticoagulation for invasive procedures; however, data to guide the perioperative […]

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Anticoagulant Therapy

May 15 2026

george

Coagulation Overview Module

We’re reviewing our Educational Modules for timeliness. Many institutions use Coagulation Overview for both introductory education and advanced review. You can complete it in <30 minutes, but you may wish to stop at intervals to observe the various diagrams in detail just by pressing the space bar. The module supplements Walenga JM, Krom KN: Chapter […]

Coagulation Factors

Aspirin Prophylaxis

The question appeared on the Diagnostic Equity site, paraphrased with the approval of site proprietor Tamara Lobban-Jones: “I’ve heard that some people take a ‘ton of baby aspirin.’ My doc told me to take only one a day. Does taking multiple tablets help with clotting? What does taking one aspirin do to the blood, and […]

Antiplatelet Therapy

VWD Test Panel: A Correction

Thanks to Dr. Emmanuel Favaloro for pointing out an error in our April 29 post, “Quick Question Results, VWF Activity.” I (Geo) had transposed the principles of the VWF:GP1bR and VWF:GP1bM. I’ve corrected the error in the April 29 post–the correct principles are that VWF:GP1bR employs ristocetin, whereas VWF:GP1bM employs a gain-of-function form of GP1b […]

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Bleeding Disorders

All Posts

Aspirin v. Clopidogrel in Dual Antiplatelet Therapy

A 2026 Review of D-dimer Reporting Variations in VTE

Cell-based Coagulation Model

Tissue Factor Activity and Ischemia

Cord Blood VWF & FVIII Levels

Clot Waveform Analysis

Perioperative Management of Antiphospholipid Syndrome Study

Coagulation Overview Module

Aspirin Prophylaxis

VWD Test Panel: A Correction

George Fritsma MS MLS

Cheat Sheets from George

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