THSNA Now a Virtual Meeting

The following announcement appears on the THSNA home page. UPDATE: In consideration of the health impacts of COVID-19 and the anticipated continued social distancing guidelines, THSNA has determined that it WILL NOT be possible to hold an in-person meeting in August. Instead THSNA 2020 will be converted to a virtual meeting in mid-end of October. […]

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Events

Jun 1 2020

george

June, 2020 QQ: Protein S Deficiency

Our June, 2020 Quick Question asks what assay we use to screen for protein S deficiency. Our purpose is to support the development of a Choosing Wisely recommendation that addresses our use of thrombosis risk factor test profiles, which customarily include a protein S assay. Thanks in advance, and please feel free to comment on […]

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Quick Question Archive

May 31 2020

george

May 2020 Quick Question: D-dimer Results

Our May, 2020 Quick Question, which attracted 70 responses, was, “What assay does your lab use to monitor DIC?” The answers were somewhat predictable, only with a twist. They were: a. FDP: 1% [1] b. D-dimer: 69% [48] c. FDP & D-dimer: 30% [21] d. Other, please comment: 0 These findings are interesting because most […]

Fibrinolysis

More on Covid and LAC

Thanks to Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc., for sending a current editorial in press, Aubignat M, Godefroy O. COVID-19 and ischemic stroke: Should we systematically look for lupus anticoagulant and antiphospholipid antibodies? Revue neurologique 2020, https://doi.org/10.1016/j.neurol.2020.05.001. Please refer to our May 6 entry on antiphospholipid syndrome and the comment from Dr. Ning Tang. The […]

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Anticoagulant Therapy

May 16 2020

george

Covid and Convalescent Plasma

Margaret and George Fritsma attended the American Society for Clinical Pathology May 11, 2020 Virtual Town Hall presentation, “Covid-19 and the Blood Bank,” now recorded and available to all. The presentation featured panel participants Kimberly W. Sanford, MD, MASCP, Virginia Commonwealth University, ASCP President-Elect; Melody Boudreaus Nelson, MS, MLS [ASCP], Laboratory Operations Manager; Advent Health, […]

Thrombophilia

Covid and Lupus Anticoagulant

Two compelling publications appear to implicate lupus anticoagulant as a key factor in prolonged PTT results documented in seriously ill Covid victims. These could account for prolonged PTTs in the absence of hemorrhage. They are: Bowles L, Platton S, Yartey N, et al. Lupus anticoagulant and abnormal coagulation tests in patients with Covid-19. Downloaded from […]

Factor Assays

May 2020 Quick Question: D-dimer

Colleague Dave McGlasson commented that some of the Covid articles from China reported D-dimer and fibrin degradation products (FDPs) on their critically ill patients, prompting our May, 2020 Quick Question, What assay do you use to monitor disseminated intravascular coagulation (DIC)? If you answer “neither,” please indicate in the comments section if you use one […]

Fibrinolysis

April, 2020 Quick Question: HEMLIBRA Results

Our April, 2020 Quick Question was: “How does your facility measure factor VIII during HEMLIBRA therapy?” Here are our answers from 29 respondents: a. One-stage PTT-based FVIII assay: 17% (5) b. Two-stage chromogenic FVIII assay: 45% (13) c. PTT-based assay calibrated to emicizumab: 10% (3) d. There is no reliable assay: 28% (8) Dr. Ali […]

Bleeding Disorders

ISTH Virtual Congress

Thanks to Elaine Benoit, Precision BioLogic Inc. for current information about the International Society on Thrombosis and Haemostasis’s Virtual 2020 Congress, planned for July 12–14. Registration is free. Click or tap here for the ISTH announcement and registration.

Events

Covid and Hemostasis

On April 22, the Washington Post published an informative and alarming article on the relationship between Covid infection and hemostatic abnormalities. Critical Covid cases involve sepsis and abnormal hemostasis, primarily venous thromboembolic disease. The most current and authoritative resources for VTE management are the American Society of Hematology Covid Q&A site, https://lnkd.in/eDeurb7, and the Anticoagulation […]

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Anticoagulant Therapy

All Posts

THSNA Now a Virtual Meeting

June, 2020 QQ: Protein S Deficiency

May 2020 Quick Question: D-dimer Results

More on Covid and LAC

Covid and Convalescent Plasma

Covid and Lupus Anticoagulant

May 2020 Quick Question: D-dimer

April, 2020 Quick Question: HEMLIBRA Results

ISTH Virtual Congress

Covid and Hemostasis

George Fritsma MS MLS

Cheat Sheets from George

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