Sept, 2020 Quick Question Reponse: Fibrinolysis

Here are our responses to the September, 2020 Quick Question, wich attracted 51 participants. How does your facility measure fibrinolysis? Plasminogen: 3 [5%] Tissue plasminogen activator [TPA]: 1 [2%] Plasminogen activator inhibitor 1 [PAI-1]: 1 [2%] Thromboelastograph [TEG]: 10 [20%] Rotational thromboelastometry [ROTEM]: 36 [71%] As we speculated the first three measures of fibrinolysis are […]

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Fibrinolysis

Sep 28 2020

george

In Vitro DOAC ID and Removal

We reported on the DOAC-Dipstick®, and four in vitro devices designed to remove interfering DOACs from specimens prepared for clot-based and chromogenic substrate assays in our 9-30-20 article [click], McGlasson DL, Fritsma GA. In vitro detection and removal of direct oral anticoagulants from patient plasma specimens. Annals of Blood 9-30-20; doi: 10.21037/aob-20-16. These devices are […]

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Anticoagulant Therapy

Sep 26 2020

george

Covid-Coag Conversation Video

Thanks to all who participated in our September 15, 2020 webinar, “COVID-Associated Coagulopathy: A Conversation about the Controversies & Confusion” [click] featuring Dr. Andrew Goodwin, University of Vermont Medical Center. Click the title line if you would like to view the webinar again or if you did not have the opportunity to attend the live […]

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Anticoagulant Therapy

Sep 18 2020

george

Dilute Thrombin Time

From Deanna Miller, Children’s Hospital of Alabama. Do you have any good references for diluted thrombin and utilization of this test? What dilution is best? 1:1 or 1:3? Hello, Deanna, and thank you for your question. We use the plasma-diluted thrombin time to measure the direct thrombin inhibitors [DTIs] dabigatran, argatroban, or bivalirudin. The assay […]

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Anticoagulant Therapy

Sep 14 2020

george

Covid-Coag Conversation 9-15-20: Reminder

Reminder: You are invited to our Tuesday, tomorrow, September 15, 2020 webinar, Covid-Associated Coagulopathy: A Conversation about the Controversies and Confusion featuring pathology expert Andrew J. Goodwin, MD, University of Vermont Medical Center Laboratory Director. Click https://conta.cc/3aMDoNp for the eblast or bit.ly/COVID-Coag to go directly to the registration page. Covid-Coag is a PACE-accredited one-hour presentation, […]

Events

PT/PTT Screening

Yesterday, 9-1-20, a colleague contacted George [me] because her physcian had ordered a PT and PTT as part of a pre-procedural workup. She asked what the PT/PTT accomplished, and both the physician and nurse practitioner offered no explanation. After considerable discussion, the PT/PTT order was canceled. I recalled a similar situation from 2011 when my […]

Screening Assays

Centrifuging for PPP

Hi, I used to work in special coag at VCU, it was over 10 years ago. When we were freezing specimens we had to double spin them at 3500 rpm for 15 minutes. Our quick-spin centrifuges for PT/PTT could cause the platelets to leak out their activation factors. Where I now work, we called Mayo […]

Specimen Management

D-dimer Reporting

Hemostasis laboratory directors are aware of the problems created by the variety of D-dimer result expressions. D-dimer reagent kit manufacturers have failed to harmonize results, in part because their reagent monoclonal antibodies possess variant specificities, and in part because some report results in “D-dimer units” [DDUs] and some in “fibrinogen equivalent units” [FEUs]. FEU values […]

Fibrinolysis

Sept, 2020 Quick Question: Fibrinolysis

Introducing our September, 2020 Quick Question, a laboratory service poll, “How do you measure fibrinolysis?” Please select your answer on the right or if you don’t see the answer you are looking for, please add your comment below.

Fibrinolysis

August, 2020 Quick Question on D-dimer Results

Our August, 2020 Quick Question asks, “What condition may account for a chronically elevated D-dimer?” We’ve had 59 respondents with a broad distribution of results: Plasma human anti-mouse antibody: 7% [4] Rheumatoid factor: 14% [8] Chronic low-grade inflammation: 24% [14] Venous thromboembolic disease: 17% [10] Disseminated intravascular coagulation: 34% [20] Other, please comment: 4% [3] […]

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Fibrinolysis

All Posts

Sept, 2020 Quick Question Reponse: Fibrinolysis

In Vitro DOAC ID and Removal

Covid-Coag Conversation Video

Dilute Thrombin Time

Covid-Coag Conversation 9-15-20: Reminder

PT/PTT Screening

Centrifuging for PPP

D-dimer Reporting

Sept, 2020 Quick Question: Fibrinolysis

August, 2020 Quick Question on D-dimer Results

George Fritsma MS MLS

Cheat Sheets from George

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Quick Question