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May 28 2026
george

A Treasure Trove of VWD Articles

The May 2026 issue of Seminars in Thrombosis and Hemostasis provides a “mother lode” of open-access VWD articles in observance of Dr. Erik von Willebrand‘s 1926 article, Hereditar Pseudohaemophili, now 100 YOA. Check with your medical library for Nilsson IM. Commentary to Erik von Willebrand’s original paper in Haemophilia. 1999;5:220-1. doi: 10.1046/j.1365-2516.1999.0320a.x. PMID: 10444292 (no […]
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Bleeding Disorders
May 26 2026
george

A 2026 Review of D-dimer Reporting Variations in VTE

Here is an open-access 2026 review that illustrates the reporting variations and application of the D-dimer assay in VTE. Hofstetter RV, Marx CE, Kraaijpoel N, Favaloro EJ, et al. Reporting of D-dimer testing in venous thromboembolism diagnostic management studies: a scoping review. J Thromb Haemost. 2026:S1538-7836(26)00190-X. doi: 10.1016/j.jtha.2026.03.005. PMID: 41839295. Abstract Background: D-dimer testing is […]
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Thrombophilia
May 23 2026
george

Cell-based Coagulation Model

Our Coagulation Overview Module, linked on May 15, 2026, may be more accurately called the Plasma-based Coagulation Overview Module. The plasma-based coagulation “cascade” model, described in Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry. 1991;30:10363–70. doi: 10.1021/bi00107a001. PMID: 1931959, is the basis for clot-based tests, the PT, PTT, TT, […]
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Coagulation Factors
May 23 2026
george

Tissue Factor Activity and Ischemia

Access this open-access article that describes a relationship between plasma TF levels, cancer-related ischemia, and elevated D-dimer: Gon Y, Kawano T, Kitano T, et al. Tissue factor activity and 1-year mortality in patients with active cancer and acute ischemic stroke: findings from the SCAN study. Res Pract Thromb Haemost. 2026;10(1):103347. doi: 10.1016/j.rpth.2026.103347. PMID: 41695667; PMCID: […]
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Arterial Thrombosis
May 15 2026
george

Perioperative Management of Antiphospholipid Syndrome Study

Click here for the open-access article, Paquette M, Miranda S, Xu Y, et al. Perioperative management of antithrombotic therapy in patients with thrombotic antiphospholipid syndrome. Blood Adv. 2026;10(9):3218–28. doi: 10.1182/bloodadvances.2026019610. PMID: 41843780; PMCID: PMC13136740. Abstract Patients with thrombotic antiphospholipid syndrome (APS) frequently require interruption of anticoagulation for invasive procedures; however, data to guide the perioperative […]
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Anticoagulant Therapy
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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In your facility, what AC is used for LAC patients with VTE?