November 2021 QQ: Case Study, Prolonged PTT, Response

Our November 2021 Quick Question Case attracted 75 responses. We asked, “A 3-YOA female with normal PT and prolonged PTT and no bleeding. What is the most likely deficiency?” Here are your responses: Factor V–3 [4%] Factor VIII–18 [20%] Factor IX–2 [3%] Factor XI–4 [7%] Factor XII–44 [59%] Factor XIII–4 [7%] Congenital factor V deficiency […]

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Coagulation Factors

Nov 22 2021

george

Platelet-Cancer Cell Uptake

Here is an open-access original research report that illustrates cancer cells’ ability to uptake and mimic platelets, leading to access to the platelet proteome, implying that platelets may support metastases: /sites/default/files/plt-ca_cell_uptake_castanheira_jth_2021.pdf

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Platelet Function Testing

Nov 22 2021

george

Anti-emicizumab

This case study is the first instance I’ve [Geo] seen describing the development of an anti-emicizumab antibody that appears to suppress hemophilia A therapy: /sites/default/files/anti-emicizumab_kaneda_jth_2021.pdf

Bleeding Disorders

Hemolysis Level and Coag Assays

A timely question from Frank Cragg, MD, Nova Scotia Health. “Hi, I have the IL 750 ready to implement but am getting conflicting information on how much hemolysis to allow. Please help. Regards, Frank Cragg MD, FRCPC [C]. Hello, Dr. Cragg, and thank you for your question, which I’ve forwarded to several experts. Although more […]

Screening Assays

Geomean: Additional Information

From Hillary Thurman: Here is some additional information, in response to Bob Gosselin’s 11-6-21 response: The RIs currently in use are the manufacturer’s suggested ranges. Each site collected screened normal samples and EP Evaluator was utilized to ensure the patient population did not fall outside this range. Each site (there are seven) currently has one […]

Validation

Geomean: Instrument Specific or System-Wide?

Hillary Thurman is looking for some insight, She writes, “We have recently standardized hemostasis instruments across our system. The rest of the system has been using a combined geometric mean for their PT reagent (same lot, same instruments), but my site has never been involved in this. In addition, they do not change the geomean […]

Validation

JTH World Thrombosis Day Virtual Issue

The International Society on Thrombosis and Haemostasis has released a virtual access Journal of Thrombosis and Haemostasis issue devoted to World Thrombosis Day, observed on October 13, 2021. Click here to access the issue, which features a number of open access articles.

Thrombophilia

November 2021 Cheat Sheet

Here is our November 2021 Cheat Sheet reviewing our October posts and announcing November events. The Cheat Sheet is pushed to our participants.

Cheat Sheets

Bioport

Bioport, founded in 2002, is Atlantic Canada’s largest Health and Life Science event, delivered virtually, November 2–5. Click here for the schedule and registration.

Events

November 2021 Quick Question: Case Study, Prolonged PTT

Our November 2021 Quick Question involves a 3-year-old female patient with no bleeding history whose pre-op PT and PTT results were PT 13.3 seconds [RI 12-6–14.6] and PTT 51 seconds [RI 25–35] and asks what is the most likely coagulation factor deficiency. Please select your answer and add your comments below.

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Factor Assays

All Posts

November 2021 QQ: Case Study, Prolonged PTT, Response

Platelet-Cancer Cell Uptake

Anti-emicizumab

Hemolysis Level and Coag Assays

Geomean: Additional Information

Geomean: Instrument Specific or System-Wide?

JTH World Thrombosis Day Virtual Issue

November 2021 Cheat Sheet

Bioport

November 2021 Quick Question: Case Study, Prolonged PTT

George Fritsma MS MLS

Cheat Sheets from George

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Quick Question