BioMarin Plans to Divest Struggling Gene Therapy

Thanks to Dean Willett of Precision BioLogic Inc. for the heads-up on BioMarin’s 10-27-25 post announcing their divestment of the hemophilia A gene transfer therapy, Roctavian. See BioMarin’s 10-27 press release.

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Bleeding Disorders

Oct 28 2025

george

October 2025 QQ: Reporting Assay Uncertainty Data Summary

Our October 2025 Quick Question was a poll that asked, “Do you support publishing assay uncertainty data with all results?” The poll attracted 13 respondents who answered: Yes: 4 (31%) No: 8 (62%) It depends: 1 (7%) While the response was small, our question attracted several vigorous comments (click). Generalizing, this hourglass figure, cited in Stroobants […]

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Quick Question Archive

Oct 27 2025

george

A Coag Conversation: Alternate Warfarin Monitoring When the Prothrombin Time is Unreliable – Part 1

Join me (Geo) and guest speaker Dr. Nicole Zantek, MD, PhD, Medical Director of the Special Coagulation Laboratory, Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, who discusses the pathophysiology of antiphospholipid antibodies, and alternative methods to monitor warfarin and DOAC anticoagulation in patients diagnosed with antiphospholipid syndrome. This is the […]

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Anticoagulant Therapy

Oct 25 2025

george

International Symposium on Intensive Care and Emergency Medicine: Nebulizer Delivery of Unfractionated Heparin

Thanks to Dave McGlasson, MS, MLS, for the heads-up about this open-access review of the International Symposium on Intensive Care and Emergency Medicine (Click Here). Bateman RM, Sharpe MD, Jagger JE, et al. 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15–18 March 2016. Crit Care. 20160;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. Erratum in: […]

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Anticoagulant Therapy

Oct 25 2025

george

The Blood Project: TTP Module

Click here for a comprehensive review of TTP. This is a segment within The Blood Project, a not-for-profit organization committed to advancing medical knowledge about the crucial role of blood in human health, disease, and therapeutics. TBP offers open-access, web-based, and expertly curated learning tools and resources with the following goals: Enhance Hematological Knowledge: TBP […]

Bleeding Disorders

Precision BioLogic Webinar: Advancing Hemophilia A Testing with a Bovine Chromogenic FVIII Assay

Listen as Precision BioLogic’s Chief Scientific Officer F. Jon Geske, PhD and Marketing Director Ian Burns chair the webinar, Advancing Hemophilia A Testing with a Bovine Chromogenic FVIII Assay. Joining them are… Tara Quinton, R&D Scientist and part of Precision BioLogic’s Chromogenic FVIII assay design team, discussing the assay’s expanded utility along with new data […]

Bleeding Disorders

Algorithm for DOAC Dipstick Application

Click here for the open-access article: Harenberg J, Gosselin RC, Cuker A, et al. Algorithm for rapid exclusion of clinically relevant plasma levels of direct oral anticoagulants in patients using the DOAC dipstick: an expert consensus paper. Thromb Haemost. 2024;124:770–7. doi: 10.1055/a-2261-1811. PMID: 38316416. Abstract Background With the widespread use of direct oral anticoagulants (DOACs), there […]

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Anticoagulant Therapy

Oct 21 2025

george

Activated Protein Complex Concentrate in Emicizumab Prophylaxis

Here is a current open-access review describing APCC usage in emicizumab therapy: Sidonio RF Jr, Young G, Escuriola Ettingshausen C, et al. Activated prothrombin complex concentrate in patients receiving emicizumab prophylaxis: from evidence to clinical practice. Res Pract Thromb Haemost. 2025;9:102926. doi: 10.1016/j.rpth.2025.102926. PMID: 40808796; PMCID: PMC12346059. Abstract Nonfactor therapies (NFTs) such as emicizumab are increasingly […]

Bleeding Disorders

University of Kansas Article About TTP

Here is an editorial review article about TTP that appears in the Spring-Summer edition of the University of Kansas “Kansas Medicine” magazine, entitled “In Their Blood.” The article features X. Long Zheng, MD, PhD, KU pathology head, who provided our January 6, 2021 webinar, “von Willebrand Factor, Friend or Foe?“

Bleeding Disorders

Underfilled Citrate Tubes

Hi George. My name is Reynaldo Caparros. I know that it has been taught and drilled in our knowledge on how we should properly fill up blue tops. This has also resulted in numerous delays in patient care. My question is, are there any studies that have been done to check the possibility that short […]

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Specimen Management

All Posts

BioMarin Plans to Divest Struggling Gene Therapy

October 2025 QQ: Reporting Assay Uncertainty Data Summary

A Coag Conversation: Alternate Warfarin Monitoring When the Prothrombin Time is Unreliable – Part 1

International Symposium on Intensive Care and Emergency Medicine: Nebulizer Delivery of Unfractionated Heparin

The Blood Project: TTP Module

Precision BioLogic Webinar: Advancing Hemophilia A Testing with a Bovine Chromogenic FVIII Assay

Algorithm for DOAC Dipstick Application

Activated Protein Complex Concentrate in Emicizumab Prophylaxis

University of Kansas Article About TTP

Underfilled Citrate Tubes

George Fritsma MS MLS

Cheat Sheets from George

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