Silica Clotting Time (SCT) as part of the LA profile

The silica clotting time (SCT) is a PTT-like assay that uses colloidal silica as its negatively charged particulate activator. It was first described in Chantarangkul V, Tripodi A, Arbini A, Mannucci PM. SCT as a screening and confirmatory test for detection of the lupus anticoagulants.Thromb Res 1992;67:355-65. The current version, HemosIL SCT, marketed by Instrumentation […]

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May 15 2008

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TTP and ADAMTS13 (Carla Clem)

Here is a question from Carla Clem at Clarian in Indianapolis. Carla works with Kim Kinney and teaches with Bernadette (Bunny) Rodak for the Clarian/Indiana University Clinical Laboratory Science program. Hi George, I am Bunny’s “partner in crime;” we team-teach in Heme at Clarian/IU. Would you please give us a kindergarten version of ADAMTS-13 with […]

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Hemolysis and Coagulation Test Results

Members of Pat Letender’s Medlab-L have been discussing the effect of hemolysis on coagulation testing. This statement appears in CLSI standard H21-A4: Samples that have visible hemolysis should not be used because of possible clotting factor activation and end point measurement interference. Some current instruments using an optical detector may have problems with end point […]

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Guest Blogger Larry Smith, Ph.D.

As you saw from my recent “Coagulation Factor Inheritance” post, I had the opportunity to assist with the University of Medicine and Dentistry of New Jersey, www.umdnj.edu, graduate hemostasis course. In addition to working with course coordinator, Elaine Keohane, PhD, I had the privilege of collaborating with my friend and colleague, Larry Smith, PhD. Larry contributed […]

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Managing Acute Bleeding

One of the priveleges I enjoy because I am married to an SBB (Margaret Giddens Fritsma MA MT (ASCP) SBB) is attending the Alabama State Association of Blood Banks semiannual dinner meeting. Last evening Marla Troughton, MD, associate director of the UAB transfusion service spoke on emerging infectious diseases that affect donor blood screening, and […]

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Coagulation Factor Inheritance: UMDNJ Grad Student Question

For January through May, 2008, I’ve had the pleasure of working with Elaine Keohane, PhD, Clinical Laboratory Science Program Director for the University of Medicine and Dentistry of New Jersey. In addition managing her program, Elaine teaches an online advanced hemostasis course for sixteen graduate Clinical Laboratory Science students. She invited me to assist. We […]

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Frozen Vs. Lyophilized Plasmas

From Kim Kinney at Clarian in Indianapolis: Hi George, I was wondering if I could get opinions on how techs feel about lyophilized vs. frozen calibrators, QC, and deficient plasmas? I am partial to frozen because I think they behave more like plasma. Lyophilized requires a reconstitution time and always seems to have a touch […]

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3.2% Vs. 3,8% Sodium Citrate

We thought we had heard the last of this discussion, but one question remains. While a lot of work was done supporting the use of 3.2% sodium citrate for coagulation testing specimens, little was done to generalize it to platelet testing. We are using 3.2% citrate specimens for aggregometry, PFA-100, and Accumetrics Ultegra, but I’ve […]

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Bivalirudin

I had promised to report some of the information we gained attending the Society for Angiography and Interventions and American College of Cardiology annual meeting held in Chicago March 29-April 1. I was particularly struck by the number of clinical trials reporting the efficacy and safety figures for bivalirudin (Angiomax) such as ISAR-REACT 3 and […]

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Bleeding Time Test

From Andrea Harper: We continue to offer bleeding time testing. I would like to offer our pathologists an alternative to replace this ancient testing. In a lecture that you gave in October, 2007 in Portland, Maine, you spoke of the PFA-100. We are a 25 bed critical access facility. I’m not sure if it would […]

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All Posts

Silica Clotting Time (SCT) as part of the LA profile

TTP and ADAMTS13 (Carla Clem)

Hemolysis and Coagulation Test Results

Guest Blogger Larry Smith, Ph.D.

Managing Acute Bleeding

Coagulation Factor Inheritance: UMDNJ Grad Student Question

Frozen Vs. Lyophilized Plasmas

3.2% Vs. 3,8% Sodium Citrate

Bivalirudin

Bleeding Time Test

George Fritsma MS MLS

Cheat Sheets from George

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