Aspirin and Lupus Anticoagulant

From Mirna Ibarra; Do aspirin or Plavix interfere with lupus anticoagulant testing in any way? Hello, and thank you for your question. No, aspirin and Plavix, which are antiplatelet drugs, should have no effect on clot-based lupus anticoagulant testing, which is performed using platelet poor plasma, which is plasma whose platelet count is less than […]

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Oct 22 2010

george

Dabigatran Cleared by FDA

The oral direct thrombin inhibitor Dabigatran, (Boehringer-Ingelheim, Pradaxa®) was cleared Tuesday, October 19 for stroke prevention in atrial fibrillation. Dabigatran is the first of the new generation of oral anticoagulants to be released to the market. The press release from Boehringer is attached. Pradaxa Press Release 10-19-10

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Early Reaction Error Message

Sir, what does early reaction error while measuring PTT signify? The patient is not on any anticoagulants. Thank you for your question. An early reaction error signifies an analytical error in which the reaction mixture clotted prior to an instrument-established minimum. This could be an error in sample management or contaminated reagent. You may find […]

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Autoplex T

George, we had a patient recently who was on Autoplex and his Dr. ordered a PTT. I am not familiar with Autoplex, can you give me some information or direct me to a website? Thank you. Yvonne Ellis MT (ASCP) Bedford Regional Medical Center Hi, Yvonne. Great question. Autoplex T (Nabi, Inc) is an activated […]

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Autoplex T

George, we had a patient recently who was on Autoplex and his Dr. ordered a PTT. I am not familiar with Autoplex, can you give me some information or direct me to a website? Thank you. Yvonne Ellis MT (ASCP) Bedford Regional Medical Center Hi, Yvonne. Great question. Autoplex T (Nabi, Inc) is an activated […]

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Glass Pipettes for Reagents?

From Carol Coker in Dallas: Our manager wants to know the “gold standard” for hydrating coagulation reagents; do most people use glass class A pipettes? Also, do you use the same pipette for multiple reagents or for just one type? Hi, Carol. I enjoyed meeting you last summer in Rochester. There would be nothing wrong with […]

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2010 Northeast Lab Conference

2010 Northeast Lab Conference The 2010 Northeast Laboratory Conference starts Tuesday, October 19 and extends through Thursday, October 21 at the Holiday Inn by the Bay, Portland, Maine. I am giving two coagulation talks: Managing Hemostasis in Trauma, Tuesday, October 19, 10-11:30 AM (cross-listed as a Blood Bank talk), and New Antithrombotics: Whatever Happened to the PT […]

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Reference Intervals for PT and PTT

Dr. Salwa Peracha sent several thought-provoking questions about PTs and PTTs, which are presented (at some length) on the next page: We perform the prothrombin time (PT) and partial thromboplastin time (PTT) manually. We consider a PT that is prolonged greater than 3 seconds past the upper limit of the reference interval as abnormal and […]

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CAP Questions on Carryover

From Kim Kinney (Clarian), I received the attached response from IL regarding one of the new College of American Pathologists (CAP) questions, HEM25175, which requires pipettes be checked for carryover after repairs or maintenance. I am also awaiting documentation for HEM25150, which requires that accuracy be checked annually.

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Low Phospholipid PTT Reagent

Another excellent question from “Elhosenymohamed” How can the dilution of the phospholipid component of the partial thromboplastin time (PTT) reagent detect antiphospholipid antibodies? Hello, again, Dr. Mohamed, and thank you for your question. Most of the PTT reagents we use for monitoring unfractionated heparin or for performing routine coagulopathy screens are formulated with a relatively […]

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All Posts

Aspirin and Lupus Anticoagulant

Dabigatran Cleared by FDA

Early Reaction Error Message

Autoplex T

Autoplex T

Glass Pipettes for Reagents?

2010 Northeast Lab Conference

Reference Intervals for PT and PTT

CAP Questions on Carryover

Low Phospholipid PTT Reagent

George Fritsma MS MLS

Cheat Sheets from George

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