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Sep 19 2025
george

A Relationship Between Radiotherapy and Venous Thrombosis

Click here for an open-access 2025 article that describes the relationship between radiotherapy and cancer-associated venous thrombosis: Gurumurthy G, Miller J, Carrier M, Khorana A, Thachil J. Radiotherapy-the not-so-insignificant contributor to cancer-associated venous thrombosis. Res Pract Thromb Haemost. 2025;9:102985. doi: 10.1016/j.rpth.2025.102985. PMID: 40837025; PMCID: PMC12362088. Abstract Venous thromboembolism is a well-established complication in patients with […]
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Thrombophilia
Sep 17 2025
george

A Review of Current and Developing DOAC Reversal Agents

Check with your medical library for this comprehensive review of current and developing DOAC reversal agents:  Gómez-Outes A, Suárez-Gea ML, Lecumberri R. When and how to use reversal agents for direct oral anticoagulants? Curr Cardiol Rep. 2023;25:371–80. doi: 10.1007/s11886-023-01858-x. PMID: 36976497. Abstract Purpose of review: Our objective is to describe currently available reversal agents for […]
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Anticoagulant Therapy
Sep 12 2025
george

Heparin Resistance in Pancreatitis

Click this open-access article to read about heparin resistance in an acute pancreatitis patient with a normal antithrombin level: Rongqin D, Zhexin B, Yuzhi L, et al. Heparin resistance in a patient with severe acute pancreatitis: a case report. Lab Med. 2025;56:570–6. doi: 10.1093/labmed/lmae126. PMID: 40237706; PMCID: PMC12417076. Here’s the abstract: Introduction: Severe acute pancreatitis […]
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Anticoagulant Therapy
Sep 12 2025
george

Cell-based Coagulation Overview

Check your medical library to read Harris NS, Marin MJ, Butenas S. Beyond prothrombin time and activated partial thromboplastin time: coagulation in vivo-an illustrated review. Lab Med. 2025;56:438–47. doi: 10.1093/labmed/lmae125. PMID: 40319459. Here’s the abstract: The steps that initiate coagulation in vivo are different from the components of prothrombin time (PT) and activated partial thromboplastin time […]
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Coagulation Factors
Sep 10 2025
george

APL Positivity Cutoffs: 99th Percentile?

For a fresh look at anticardiolipin antibody and anti-β2-GP1 analysis decision points, click Anunciación-Llunell A, Marques-Soares J, Ockova M, et al. The absence of standardization in antiphospholipid antibody testing may favor the use of 99th percentile cutoffs in antiphospholipid syndrome classification. Res Pract Thromb Haemost. 2025;9:102967. doi: 10.1016/j.rpth.2025.102967. PMID: 40761700; PMCID: PMC12320162.
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Thrombophilia
Sep 10 2025
george

Poster: Monitoring FVIII in Hemophilia Patients Treated with Bypassing Therapeutics

To review the PBI poster presented at the 2025 ISTH meeting, click Effect of Mim8 and Emicizumab on Factor VIII Recovery by a Novel, Bovine Chromogenic FVIII Assay. Tara Quinton, Meghan Bruhm, Karen M. Black, Ali Sadeghi-Khomami. Precision BioLogic Inc., Dartmouth, Nova Scotia, Canada. The poster illustrates the validity of bovine reagent-based chromogenic substrate FVIII […]
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Bleeding Disorders
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George Fritsma MS MLS

George Fritsma is a medical laboratory scientist, educator, and author. George  is a member of the International Society on Thrombosis and Hemostasis, the International Society for Laboratory Hematology, and the American Society for Clinical Laboratory Science.

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What VWD subtype Is caused by a VWF gain of function?