August 2025 CAP Today: D-dimer Reporting and INR Are Variables That Matter

In follow-up to their July 2025 CAP Today article, A Deep Dive into Key Hemostasis Testing Variables, Drs. Andrew Goodwin and Eric Salazar present external quality improvement data on the PT–INR, D-dimer, and VET in their August 2025 article, D-dimer Reporting and INR Are Variables That Matter. Their article in particular examines the confusion over […]

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Anticoagulant Therapy

Dec 26 2025

george

Analytical Dilemmas in Lupus Anticoagulant Testing

Click here to read an open-access review by Moore GW. Analytical Dilemmas in Lupus Anticoagulant Testing. Explor Immunol. 2023;3:300–24 DOI: https://doi.org/10.37349/ei.2023.00104 Abstract Accurate lupus anticoagulant (LA) detection is crucial to antiphospholipid syndrome (APS) diagnosis. Detection is based on LA functional behavior in coagulation assays irrespective of epitope specificity. LA screening tests employ dilute phospholipids to […]

Arterial Thrombosis

AI in Thrombosis and Hemostasis

Here is an open-access article on the efficacy of artificial intelligence in hemostasis: Altememi MA, Favaloro EJ, Islam MZ, Santhakumar AB. Artificial intelligence and machine learning in thrombosis and hemostasis: a scoping review of clinical and laboratory applications, challenges, and future directions. Clin Chem Lab Med. 2025. doi: 10.1515/cclm-2025-1450. PMID: 41400592. Abstract This scoping review […]

Validation

Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

A summary by Dr. Wolfgang Miesbach: A potential landmark thrombolytic innovation presented at ASH 2025. Thrilled by the exciting Phase 1 data presentation by Marie Scully and co-authors on TGD001, a groundbreaking novel von Willebrand factor (VWF)-targeting thrombolytic: First-of-its-kind mechanism: TGD001 is an antibody-enzyme fusion protein—specifically, an anti-VWF antibody fragment fused to a urokinase catalytic domain. […]

Arterial Thrombosis

Editorial: Thrombophilia Diagnosis–Genetic or Functional Testing

Check with your medical library for Favaloro EJ, Moore GW, Pasalic L. Diagnosing thrombophilia: the case for genetic or functional testing? Expert Rev Mol Diagn. 2025:1-6. doi: 10.1080/14737159.2025.2588621. PMID: 41211955. Introduction The term thrombophilia defines a condition in which there is an elevated risk of thrombosis, usually venous thromboembolism (VTE), generally encompassing deep vein thrombosis […]

Thrombophilia

Platelet Function Preservation Following Cell Salvage

Thanks to colleague Dave McGlasson, MS, MLS for identifying this open-access original research study that describes the effects of intraoperative cell salvage on platelet function. Blum LV, Sertdere F, Iken S, et al. Preservation of platelet function after intraoperative cell salvage using the i-SEP same device in cardiac surgery. J Cardiothorac Vasc Anesth. 2025:S1053-0770(25)01058-4. doi: […]

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Platelet Function Testing

Dec 11 2025

george

Thrombotic Thrombocytopenic Purpura Sequelae

An ASH ’25 summary by Dr. Wolfgang Miesbach: iTTP remission ≠ cure–the vascular injury persists. TTP as a cardiovascular disease equivalent. I just finished Dr. Senthil Sukumar’s session on long-term iTTP management. This completely changed how I think about these patients, as illustrated: 28.6% of survivors → major cardiovascular events 50% → silent cerebral infarcts (vs […]

Thrombophilia

Anesthesiologists’ Approach to Perioperative Bleeding Management

ASH ’25 Report from Dr. Wolfgang Miesbach: Perioperative Bleeding Management: What 1,030+ U.S. Anesthesiologists Think About Current Challenges 50.6% practiced primarily at academic medical centers, while 42.3% worked in community hospitals, with additional representation from military/VA hospitals (3.7%). Nearly half (48.4%) worked at Level I trauma centers. The Progress… Prothrombin complex concentrates (PCCs) have become […]

Bleeding Disorders

Hemophilia Rx: “Paradox of Choice”

An ASH ’25 report from Dr. Wolfgang Miesbach: The “Paradox of Choice” is very real in Haemophilia right now. I just caught Dr. Mark Reding’s insightful presentation at ASH25, and it really highlighted that having more options doesn’t actually make the decision easier. In fact, it makes it harder. We’re looking at a massive toolkit […]

Bleeding Disorders

Associations of FVIII & FIX Levels with CVD and CVD Mortality

Go to your medical library to access this provocative journal article: Harris K, Woodward M, Folsom AR, et al. Associations between plasma levels of coagulation factors VIII and IX and incident cardiovascular disease and mortality: systematic review and meta-analysis. J Thromb Haemost. 2025:S1538-7836(25)00598-7. doi: 10.1016/j.jtha.2025.09.008. PMID: 41038279. Abstract Background: Associations of plasma levels of coagulation […]

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Arterial Thrombosis

All Posts

August 2025 CAP Today: D-dimer Reporting and INR Are Variables That Matter

Analytical Dilemmas in Lupus Anticoagulant Testing

AI in Thrombosis and Hemostasis

Discussion of Phase I Data on a Unique anti-VWF Thrombolytic

Editorial: Thrombophilia Diagnosis–Genetic or Functional Testing

Platelet Function Preservation Following Cell Salvage

Thrombotic Thrombocytopenic Purpura Sequelae

Anesthesiologists’ Approach to Perioperative Bleeding Management

Hemophilia Rx: “Paradox of Choice”

Associations of FVIII & FIX Levels with CVD and CVD Mortality

George Fritsma MS MLS

Cheat Sheets from George

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