PT and PTT Mixing Studies: Saline PNP Dilution

This post is reprised from 2013: From Courtney Jackson at Oschner in Louisiana: We use a commercial pooled normal platelet-free plasma (PNP) for our prothrombin time (PT) and partial thromboplastin time (PTT) mixing studies. When we mix it with saline for our controls, we don’t get a normal PTT until the ratio is 4 plasma to 1 saline. We […]

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Mixing Studies

May 17 2015

george

Mixing Studies with Controls

Thanks to all who attended our free webinar, Improving Acute Care with Coagulation Mixing Studies, Wednesday, May 13, sponsored by Precision BioLogic Inc. You can see and hear an archived copy of the entire webinar by registering on the Precision BioLogic web site by June 12. The webinar was hosted by CACMLE. There was an […]

Mixing Studies

DVT with Thrombocytopenia

Here is a case that George heard about on Saturday, May 16. An ultrasound revealed two blood clots in a man’s leg. After two days on Coumadin and Lovenox (LMWH) his platelet count was 4,000/uL so his doctor discontinued the Coumadin. The man had been previously diagnosed with ITP and his doctor wants to arrange […]

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Anticoagulant Therapy

May 13 2015

george

More on Prekallikrein Deficiency

Here is an comment on Tracy Dixon’s prekallikrein deficiency case from Dr. Tom Exner, Haematex, Sydney, Australia. Hi, George, thanks for the interesting case; from Australia of all places! I’ve written up a couple of such cases many years ago. PKK and HMWK-deficient plasmas may be less readily available these days but the antibodies are […]

Factor Assays

ASCLS-GA Meeting Saturday, May 16 in Marietta

The Georgia branch of the American Society for Clinical Laboratory Science holds its annual meeting this Saturday, May 16, 7 AM–6 PM at the Hilton Atlanta/Marietta Hotel and Conference Center, 500 Powder Springs Street, Marietta, GA. The Fritsma Factor will exhibit at the meeting and will hold a drawing for a signed copy of the […]

Events

Prekallikrein Deficiency

From Tracy Dixon, Western Australia Department of Health. Hi George, We have a case currently of an elderly man with metastatic melanoma and liver involvment who is giving us a consistently long APTT (PTT) with a silica reagent, often >200 seconds. Prolonged incubation with the silica reagent has shortened this to around 60 seconds. The […]

Factor Assays

Rare Bleeding Disorders

I thank Marisa Marques, MD, Professor, Pathology Department, University of Alabama at Birmingham, for introducing me to a concise review article, Palla R, Peyvandi F, Shapiro AD. Rare bleeding disorders” diagnosis and treatment. Blood 2015;125:2052–61, available free from The American Society of Hematology. The article answers many questions about the rare deficiencies of factors II, […]

Bleeding Disorders

Platelet Function Testing

From Ahmed Siddig Akasha: Please inform me about simple procedure of platelet aggregation test, the principle, procedure, and results interpretation and the normal values. Thank you. Hello, and thank you for your question, which provides me the opportunity to highlight our audio PowerPoint educational modules. You will find the information you request in modules 29–34, […]

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Platelet Function Testing

May 4 2015

george

Mixing Studies Webinar

George presents a live webinar on Wednesday, May 13, 1–2 PM Eastern Time entitled Improving Acute Care with Coagulation Mixing Studies. The free presentation is sponsored by Precision BioLogic, Inc and is accredited for 1 CEU. Select registration for our online registration form and for additional details. Deadline is May 12, and we hope to […]

Mixing Studies

ASCLS-Kansas Annual Meeting

The Kansa Society for Clinical Laboratory Science and the Wheatlands Clinical Laboratory Management Association host their annual joint meeting on April 28 and 29, 2015 at the Doubletree by Hilton, Wichita Airport, Wichita, Kansas. George Fritsma will provide two hemostasis presentations: “Managing Hemophilia Therapy, From Rasputin to Recombinants,” Tuesday, April 28, 9:30–10:50. Click here for […]

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Events

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PT and PTT Mixing Studies: Saline PNP Dilution

Mixing Studies with Controls

DVT with Thrombocytopenia

More on Prekallikrein Deficiency

ASCLS-GA Meeting Saturday, May 16 in Marietta

Prekallikrein Deficiency

Rare Bleeding Disorders

Platelet Function Testing

Mixing Studies Webinar

ASCLS-Kansas Annual Meeting

George Fritsma MS MLS

Cheat Sheets from George

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