Review: Non-antithrombotic Strategies for Venous Thromboembolism Prophylaxis

Check with your medical library for this provocative review of VTE prevention: Gurumurthy G, Thachil J. Nonanticoagulant strategies for venous thromboembolism prophylaxis. Semin Thromb Hemost. 2026;52:236–47. doi: 10.1055/a-2712-3534. PMID: 41092960. Abstract Venous thromboembolism (VTE) remains a major cause of preventable morbidity and mortality. Prophylaxis with anticoagulation is limited by bleeding risk, contraindications, and patient-specific factors. […]

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Thrombophilia

Feb 19 2026

george

CAP Today: Hemostasis Testing While on DOACs

This open-access January 26 CAP Today document features the opinions of several experts as they address the limitations of coagulation testing in patients taking DOACs, such as dabigatran, rivaroxaban, or apixaban, and speculates on the coagulation effects of the upcoming anti-XI antithrombotics: Direct Oral Anticoagulants–New Guidance, Lab Testing.

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Anticoagulant Therapy

Feb 17 2026

george

Case: Essential Thrombocythemia

Here is a February 16, 2026, question addressed to the Diagnostic Equity website: “I have essential thrombocythemia (ET). Can I live a normal life, and will my labs be a barometer for how I am doing?” Here is the response excerpted by colleague Kathryn Golab, DCLS: ET is a disorder of the early blood-forming cells […]

Arterial Thrombosis

Letter to 2024 NEJM Links Adenoviral Anti-PF4 to VITT

Click here for the full news release from Flinders University News: New research, led by Flinders University and international experts, has finally uncovered how a rare blood-clotting condition can occur after some COVID-19 adenovirus-based vaccines or after a natural adenovirus infection. First paragraph: To the Editor: Disorders caused by antibodies against platelet factor 4 (PF4) gained […]

Arterial Thrombosis

A History of Russell Viper Venom

Here’s an amusing history of RVV and Dr. Russell, who named the venom. You may retrieve the article from your medical library. Thachil J. Russell viper venom: a journey from the bedside to the bench and back to the bedside. Semin Thromb Hemost. 2024;50:115-118. doi: 10.1055/s-0043-1771269. PMID: 37506733. Abstract Russell Viper Venom (RVV) is widely […]

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Anticoagulant Therapy

Feb 13 2026

george

What is Red Light Therapy?

Check with your medical library for this in-depth review of red light Rx efficacy: Fan BE, Pasalic L, Hew YY, Lippi G, Favaloro EJ. Red light therapy in thrombosis and hemostasis. Semin Thromb Hemost. 2026;52:266–72. doi: 10.1055/a-2717-5157. PMID: 41062078. Abstract Red light therapy is emerging as a potential non-pharmacological modulator of thrombosis and hemostasis. Photobiomodulation […]

Antiplatelet Therapy

Enhanced Coagulation Potential FVIII

See this open-access article that describes a synthetic enhanced coagulation potential FVIII. This preparation reflects the enhanced activity FIX Padua. Kashiwakura Y, Nakajima Y, Horinaka K, et al. Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy. Blood. 2026;147:402–15. doi: 10.1182/blood.2025028481. PMID: 41198051. Abstract Click here for the visual […]

Bleeding Disorders

Normalized Activated Protein C Sensitivity Ratio Predicts VTE in OCR

Here is an open-access report on a noteworthy primary research piece detailing an assay that predicts VTE risk associated with oral contraceptives: Morimont L, Creinin MD, Gaspard U, Foidart JM, and Douxfils J. Predicting venous thromboembolism risk from an endogenous thrombin potential-based normalized activated protein C sensitivity ratio assay: toward early assessment of combined oral […]

Thrombophilia

ADAMTS-13 Conformation

What if we’ve been monitoring the wrong biomarker in iTTP remission? In immune-mediated TTP, we obsess over ADAMTS13 activity to predict relapse. But what if activity isn’t the earliest warning sign? A fascinating new study suggests the real signal may be hiding in ADAMTS13 conformation. Here is the open-access link: Joly BS, Roose E, Dekimpe […]

Thrombophilia

Review: VWD Type 2A

From Emmanuel Favaloro, PhD, Editor-in-Chief, Seminars in Thrombosis and Hemostasis: 2026 marks the 100th anniversary of the initial publication of a bleeding disorder, “pseudo-hemophilia’ that was later to become known as von Willebrand disease. Seminars in Thrombosis and Hemostasis will publish several papers on VWD in 2026. This is the first one in the queue–on […]

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Bleeding Disorders

All Posts

Review: Non-antithrombotic Strategies for Venous Thromboembolism Prophylaxis

CAP Today: Hemostasis Testing While on DOACs

Case: Essential Thrombocythemia

Letter to 2024 NEJM Links Adenoviral Anti-PF4 to VITT

A History of Russell Viper Venom

What is Red Light Therapy?

Enhanced Coagulation Potential FVIII

Normalized Activated Protein C Sensitivity Ratio Predicts VTE in OCR

ADAMTS-13 Conformation

Review: VWD Type 2A

George Fritsma MS MLS

Cheat Sheets from George

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