Charcoal Adsorbents Remove Anti-FXIa Interference

My (Geo) audio PowerPoint, Managing Direct Oral Anticoagulants, was posted in 2021. One of the final slides indicates experimental anticoagulant formulations designed to suppress FXI activation, aiming to reduce thrombotic risk without increasing the risk of bleeding. Click open-access article Buckley GT, Crowley MP, Harte JV. Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal-based adsorbents. J Thromb Haemost. 2025;23:2819-2829. doi: 10.1016/j.jtha.2025.05.030. PMID: 40499719. to learn about two anti-FXIa anticoagulants under development and a means for removing them from blood specimens to avoid interference with coagulation tests. Meanwhile, the 2021 module mentions a direct anti-Xa agent named Betrixaban, which was actually withdrawn from the market for economic, not safety-related issues.