Posts - Fibrinolysis

Sep 27, 2019 12:42pm
A colleague has seen references to a "High-sensitivity" D-dimer assay. George answered he's not heard of this, perhaps it is just a synonym for a standard D-dimer assay. If you have any experience with this, please respond to or comment below.  
Sep 27, 2019 9:55am
From Heather DeVries, Indiana University Medical Center. I’m seeking some advice on how to handle D-dimers in patients with elevated hematocrits. I saw a post on this subject in Fritsma Factor back in 2013. CLSI H59-A says to follow H21-A5 in general, which of course says to correct the anticoagulant volume. IL ’s package insert for D-dimers also says to follow H21-A5. So, I revised the D-dimer procedure for our system to include adjusted tubes. Now I am being asked by one of our sites if that is really necessary. My mind goes to a possible dilutional effect, which is what the post from 2013 mentions as well. But I didn’t see any follow up and am curious to know which direction the conversation took.
Jul 24, 2019 6:14am
Here is a follow-up on yesterday's (July 23, 2019) case study describing chronically elevated D-dimer. Our correspondent has graciously offered her permission to post her message (anonymously, of course).
1 Comment
Jul 23, 2019 12:09pm
Dear George, I am a 42 year old African American women in fairly good health. I am obese and I live a partly active life. I went to the emergency room back in January of this year for chest pain and palpitations. While there they did a D-dimer test and a chest CT scan. I was told that my CT scan was normal but some lung nodules were noticed and my D-dimer was elevated. I was told to follow up with my doctor.