A patient experiences chronic moderate bleeding from a surgical site and venipuncture sites over 48 months. The bleeds consistently require intervention. There is no epistaxis and minor bruising. The only diagnostic laboratory result is impaired aggregation epinephrine and ADP agonists, and absence of arachidonic acid-induced aggregation. All other hemostasis and hematology results report within their respective reference intervals. The results appear to indicate a platelet signal transduction (signalling) disorder, or "aspirin-like disorder (ALD)." Platelet signaling disorders are often described, but seldom defined.
Posts - Platelet Function Testing
Jan 29, 2019 2:21pm
Jan 27, 2019 11:35am
George has attached Anne Paxton's article, Navigating the Quandaries of Coagulation Testing, (click or tap) featuring Drs. Michael Laposata, Dot Adcock, and Kristi Smock. The article features the need for laboratory-clinician communication.
Oct 30, 2018 11:16am
Here is a reference to a brilliant review of current aspirin efficacy studies, focusing especially on the prospective random control trial ASPREE published in the September, 2018 New England Journal of Medicine.
Nov 15, 2017 7:55am
George found a provocative ASH platfom presentation abstract by A. Cap, "Targeting Hemorrhage: Alternative Storage of Platelets for Hemostatic Transfusion." describing alternatives to current platelet concentrate storage guidelines. Saturday, December 9, 9:30 or 4.