Hi. I am Krishna. I would like to ask about the interpretation of an APTT (PTT ) mixing study that we performed by calculating the Rosner index:
Posts - Mixing Studies
Jul 5, 2017 9:08am
From Dr. Deanna Franke, Carolinas HealthCare System: Thank you so much for all the valuable resource information on your website! My question relates to use of variations of mixing studies--specifically the use of dilutions during mixing studies: 1:1 vs 4:1 and saline mix. In what situations is it appropriate to use these variations?
Jun 29, 2017 5:32pm
The stem of our June, 2017 Quick Question was, "In a PTT mixing study, the patient's initial PTT is 67 s, RI 25–35. The PTT is repeated after mixing 1:1 with NP , and the new result is 63 s, NP 30 s. What do you do next?" This was a quiz question with a correct answer, rather than the usual survey question. The choices were:
Jun 29, 2017 7:38am
Dr. Ali Sadeghi-Khomami, Precision BioLogic Inc., provided these in-depth technical questions about the Nijmegen Bethesda Assay (NBA), which we use to quantitate specific factor inhibitors such as anti-factor VIII or anti-factor IX. George forwarded his questions to Connie Miller and Amanda Payne, US Centers for Disease Control and Prevention (CDC ) who have been working on NBA accuracy and precision upgrades for several years. Here are Dr. Ali's questions and answers provided by Drs. Miller and Payne; thanks to all for your support.