From Deanna Miller, Children's Hospital of Alabama. Do you have any good references for diluted thrombin and utilization of this test? What dilution is best? 1:1 or 1:3?
Posts - Global Hemostasis Assays
Sep 18, 2020 7:38pm
Aug 26, 2020 6:26pm
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Jan 22, 2018 10:41am
From Alan Neal, Pathlab, NZ. Just wanted a private conversation about the January 11, 2018 Fritsma Factor entry, "POC and Plasma-Based PT/INRs." I do not agree with the comments made within this article and challenge the logic used. Essentially, if monitoring an enzymatic pathway such as coagulation, with the 'detector' being used is fibrinogen to fibrin, then that rate of reaction will be dependent on the substrate concentration, i. e., fibrinogen, and the sensitivity of the analyser to detect the end point. So if no or reduced fibrinogen or dysfibrinogen, then reduced Vmax and hence PT/INR will be more prolonged than test system using a clot based end point detection.